Medindia LOGIN REGISTER
Medindia
Kidney Disease: Patient Outcomes and Symptoms Progression

Kidney Disease: Patient Outcomes and Symptom Progression

by Dr. Trupti Shirole on Oct 31 2022 11:39 AM
Listen to this article
0:00/0:00

Highlights:
  • The prevalence of each symptom ranged from 24% (chest discomfort) to 83% (fatigue) among people with various degrees of chronic kidney disease who were not receiving dialysis, and 98% of participants reported having at least one symptom
  • Patients with a ‘worse symptom score and worsening trajectory’ of symptoms were more likely to require dialysis in the future and to pass away before starting treatment
One-third of people with various degrees of chronic kidney disease (CKD), not receiving dialysis, who responded to annual questionnaires about their symptoms might have a ‘worse symptom score and deteriorating trajectory’ of symptoms. These patients had particularly significant risks of subsequently needing dialysis and of passing away before starting treatment.
The Kidney Disease Quality of Life-36 questionnaire was completed by 2,787 persons in France who had CKD but weren’t receiving dialysis for the study by Moustapha Faye, MD (CHRU Nancy, Université Cheikh Anta Diop de Dakar), and his colleagues.

Symptoms of Chronic Kidney Disease Patients

98% of participants reported experiencing at least one symptom, with the prevalence of each symptom ranging from 24% (chest discomfort) to 83% (fatigue). 690 people began kidney replacement therapy (KRT), such as dialysis, after a median follow-up of 5.3 years, while 490 participants passed away before KRT.

Symptom Trajectory Profile in Kidney Disease Patients

The team found two types of symptom trajectory profiles: a ‘worse symptom score and worsening trajectory’ in 31% of participants, which was defined by a low initial symptom score that got worse by more than 10 points (on a scale of 0-100) over time, and a ‘better symptom score and stable trajectory’ in 69% of participants, which was defined by a high initial score that stayed stable over time.

Better quality of life, more risk factors for CKD progression at baseline, a higher risk of KRT, and a higher chance of death before KRT were all present among participants in the group of ‘worse symptom score and worsening trajectory’ than in other people.

“In addition to the existing classifications of CKD, it is possible to monitor symptoms actively and classify patients according to their progression. This monitoring should involve practitioners and patients,” said Dr Faye. “This active symptom tracking will allow early therapeutic interventions to be planned to help manage different symptoms.”

Source-Medindia


Advertisement