About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Eye Drops to Replace Injections for Retinal Diseases
Advertisement

Eye Drops to Replace Injections for Retinal Diseases

Font : A-A+

Highlights:
  • A new eye drop that may replace injections for retinal diseases has been developed.
  • This novel drug is called Sylentis SYL136001v10.
  • It can enter the cells of the retina and blocks the formation of new blood vessels by intravitreal drops.

A compound to treat diseases of the retina that can be administered by ophthalmic drops instead of intraocular injections has been developed by the Spanish firm Sylentis.

This new drug may be used as effective eye-drops for age-related macular degeneration and diabetic retinopathy.

Advertisement


The drug SYL136001v10, presented by the PharmaMar group company, is still in the preclinical phase. "Its effectiveness has been proven in animal models and trials with humans will begin at the end of 2018", said Covadonga Pañeda, Manager at Sylentis.

Objective - to control the formation of new blood vessels in the retina
Pañeda goes on to explain that this compound "is a small interfering RNA (siRNA) designed to silence the expression of NRARP, a protein that controls the formation of new blood vessels in the retina".
Advertisement

In this way, she says, "the drug exerts its action by entering the cells of the retina, where it prevents the synthesis of this protein and blocks the formation of new vessels, which is one of the fundamental characteristics of degenerative diseases of the retina".

The compounds currently used to treat these diseases are based on large antibodies that cannot penetrate from the ocular surface to the retina, so they must be administered by intravitreal injections.

Therefore, "patients suffering from age-related macular degeneration or diabetic retinopathy have to go to the hospital where the treatments are performed with ocular injections, which is annoying and painful, and also involves a significant financial investment for the health system", says Covadonga Pañeda.

Efficacy in animal models
However, she notes, "siRNA, like SYL136001v10, are up to 10 times smaller than these treatments. Their size allows them to penetrate the retina and inhibit the formation of new blood vessels after their application in ophthalmic drops, as we have shown in animal models".

In particular, "efficacy studies have shown that the reduction of NRARP in the retina by means of siRNA leads to the regression of angiogenic retinal lesions and that the observed reductions are equivalent to those of anti-VEGF, which is the current treatment standard for these diseases with ocular injections", stresses the R&D manager.

The firm, located in Tres Cantos (Madrid), plans to take charge of the first clinical efficacy studies. Once the proof of concept in humans has been demonstrated, it will try to license the drug to a multinational.

Reference :
    A Drug to Treat Retinal Diseases with Drops Instead of Injections - (http://www.agenciasinc.es/en/News/A-drug-to-treat-retinal-diseases-with-drops-instead-of-injections)

    Source: Eurekalert

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Nervous Tic Eye Vision LASIK Surgery Facts Allergy Eye Drops Retinal Detachment Routine Eye Examination Quiz On Eye Donation Floppy Iris Syndrome Eyelid Bump 

Most Popular on Medindia

Accident and Trauma Care Nutam (400mg) (Piracetam) Drug - Food Interactions Drug Interaction Checker Blood Donation - Recipients Calculate Ideal Weight for Infants Noscaphene (Noscapine) How to Reduce School Bag Weight - Simple Tips Daily Calorie Requirements Iron Intake Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Eye Drops to Replace Injections for Retinal Diseases Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests