About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Can Parkinson's Disease Risk be Lowered in IBD Patients?

Font : A-A+

Highlights
  • A new therapy can help lower the risk of Parkinson's disease in inflammatory bowel disease (IBD) patients
  • IBD patients are at a greater risk of developing Parkinson disease
  • Treating IBD patients with anti-tumor necrosis factor therapy can lower the risk of Parkinson’s

Can Parkinson's Disease Risk be Lowered in IBD Patients?

Inflammatory bowel disease (IBD) can increase the risk of developing Parkinson's disease. However, a new therapy can help treat and prevent Parkinson's disease, reveals a new study.

The study was conducted by the research team at the Icahn School of Medicine at Mount Sinai and published the study in JAMA Neurology.

Advertisement


Link between Parkinson's and Inflammatory Bowel Disease

Patients with IBD were found to be at a 28 percent higher risk of developing Parkinson's disease than those patients without IBD.

In this study, the research team suggests that treating IBD patients with anti-Tumor Necrosis Factor-alpha (anti-TNFα) therapy can reduce the risk of developing Parkinson's disease.
Advertisement

Anti-TNFα, a monoclonal antibody is commonly used to control inflammation in patients with IBD. It can not only lower the risk in IBD patients, but also in the general population.

These results can help in the screening of IBD patients for Parkinson's disease much better, as the onset of IBD precedes Parkinson's disease by decades.

The research team also provides evidence to support exploring anti-TNFα therapy in preventing Parkinson's disease in individuals who are at-risk.

Previous studies show a link between genetic and functional connections in IBD and Parkinson's disease patients. However, clinical evidence linking the two has been limited.

Some genetic variants have been identified by the research team that contributes to either an increased risk of both Parkinson's disease and Crohn's disease or a decreased risk of both diseases.

These results have led the research team to study the co-occurrence of these two diseases further.

Effect of Anti-TNFα Therapy

"Systemic inflammation is a major component of IBD, and it's also thought to contribute to the neuronal inflammation found in Parkinson's disease. We wanted to determine if anti-TNFα therapy, could mitigate a patient's risk of developing Parkinson's disease," explained Inga Peter, Professor in the Department of Genetics and Genomic Sciences at Mount Sinai and lead investigator of the study.

In this study, the team found a 78 percent reduction in the incidence of Parkinson's disease among IBD patients, especially in those treated with anti-TNFα therapy than those who were not treated with anti-TNFα therapy.

Previously, it was thought that anti-TNFα therapy has limited effect on the central nervous system, it is a site where molecular mechanisms of Parkinson's disease are found, as the large molecules in the anti-TNFα compounds cannot pass through the blood-brain barrier.

In this study, the results show that it is not necessary for the drug to pass through the blood-brain barrier to treat or prevent inflammation within the central nervous system, allowing the large molecules of the compound to pass through the blood-brain barrier.

Parkinson's disease is the most common late-life neurodegenerative disease, which affects nearly 1 percent to 2 percent of people who are 60 years or older.

"Current therapies for Parkinson's disease focus on improving symptoms. Our findings provide promising insights that support further investigations into how reducing systemic inflammation could help treat or prevent Parkinson's disease," said Peter.



Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Hannah Joy. (2018, April 24). Can Parkinson's Disease Risk be Lowered in IBD Patients?. Medindia. Retrieved on Aug 10, 2022 from https://www.medindia.net/news/healthwatch/can-parkinsons-disease-risk-be-lowered-in-ibd-patients-178954-1.htm.

  • MLA

    Hannah Joy. "Can Parkinson's Disease Risk be Lowered in IBD Patients?". Medindia. Aug 10, 2022. <https://www.medindia.net/news/healthwatch/can-parkinsons-disease-risk-be-lowered-in-ibd-patients-178954-1.htm>.

  • Chicago

    Hannah Joy. "Can Parkinson's Disease Risk be Lowered in IBD Patients?". Medindia. https://www.medindia.net/news/healthwatch/can-parkinsons-disease-risk-be-lowered-in-ibd-patients-178954-1.htm. (accessed Aug 10, 2022).

  • Harvard

    Hannah Joy. 2021. Can Parkinson's Disease Risk be Lowered in IBD Patients?. Medindia, viewed Aug 10, 2022, https://www.medindia.net/news/healthwatch/can-parkinsons-disease-risk-be-lowered-in-ibd-patients-178954-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips A-Z Drug Brands in India Sinopril (2mg) (Lacidipine) Turmeric Powder - Health Benefits, Uses & Side Effects Calculate Ideal Weight for Infants Color Blindness Calculator Find a Doctor Loram (2 mg) (Lorazepam) Drug Interaction Checker Pregnancy Confirmation Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR