- Antidepressants are used to manage chronic pain and behavioral and psychological symptoms of dementia apart from depression.
- The risk of hip fractures among elderly with Alzheimer's Disease who used antidepressants was nearly double .
Antidepressant use nearly doubles the risk of hip fracture among community-dwelling persons with Alzheimer's disease.
This was according to a new study from the University of Eastern Finland.
Antidepressants are used not only for the treatment of depression, but also to manage chronic pain, behavioral and psychological symptoms of dementia, including insomnia, anxiety and agitation.
In addition, other risk factors for falling should be carefully considered during the antidepressant treatment.
The data for the study was based on the Finish register-based MEDALZ cohort.
The study population comprised of all community-dwelling persons diagnosed with Alzheimer's disease in Finland between 2005-2011, and their matched controls.
It included 50,491 persons with mean age 80 years and 100,982 persons without the disease. For each person with Alzheimer's disease, two controls without the disease were matched by age and sex.
The follow-up was 4 years from the date of Alzheimer's disease diagnosis or a corresponding date for controls.
The risk of hip fracture among controls was two times higher with antidepressant use.
But the relative number of hip fractures was higher among people with Alzheimer's disease compared to controls.
The increased risk was associated with all of the most frequently used antidepressant groups like:
- selective serotonin reuptake inhibitors (SSRI drugs)
- selective noradrenaline reuptake inhibitors (SNRI drugs)
The increased risk of hip fractures with antidepressant use was highest at the beginning of antidepressant use and remained elevated even 4 years later.
The findings were published in the International Journal of Geriatric Psychiatry.
- Sanna Torvinen-Kiiskinen et al. Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer's disease. International Journal of Geriatric Psychiatry; (2017) DOI: 10.1002/gps.4667
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Dr. Meenakshy Varier. (2017, January 12). Antidepressant Use Increased Risk of Hip Fractures Among Elderly With Alzheimer's Disease. Medindia. Retrieved on Sep 28, 2022 from https://www.medindia.net/news/healthwatch/antidepressant-use-increased-risk-of-hip-fractures-among-elderly-with-alzheimers-disease-166931-1.htm.
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Dr. Meenakshy Varier. "Antidepressant Use Increased Risk of Hip Fractures Among Elderly With Alzheimer's Disease". Medindia. https://www.medindia.net/news/healthwatch/antidepressant-use-increased-risk-of-hip-fractures-among-elderly-with-alzheimers-disease-166931-1.htm. (accessed Sep 28, 2022).
Dr. Meenakshy Varier. 2021. Antidepressant Use Increased Risk of Hip Fractures Among Elderly With Alzheimer's Disease. Medindia, viewed Sep 28, 2022, https://www.medindia.net/news/healthwatch/antidepressant-use-increased-risk-of-hip-fractures-among-elderly-with-alzheimers-disease-166931-1.htm.