- New disease activities in multiple sclerosis patients detected through MRI now correlate with the presence of a nerve protein in the blood.
- Relapsing-remitting multiple sclerosis is characterized by surges of neurological symptoms followed by periods of remission.
- The nerve protein is likely to make its mark as a new biomarker and the blood test as a cost-effective alternative to MRI.
A simple blood test can now monitor a nerve protein in the blood of people with the relapsing-remitting form of multiple sclerosis (MS) - the levels of the protein are higher in patients when they are new disease activity.This study was published in Neurology® Neuroimmunology and Neuroinflammation.
The nerve protein in concern is the neurofilament light chain protein (NfL) found in neurons; it can be detected in the blood stream and spinal fluid when nerve cells die. The NfL is a major component of the neuronal cytoskeleton and may be present to function primarily as structural supports for the axon and help in axonal and dendritic branching and growth.
"Since MS varies so much from person to person and is so unpredictable in how the disease will progress and how people will respond to treatment, identifying a biomarker like this that can help us make predictions would be very helpful," said study author Kristin N. Varhaug, MD, of the University of Bergen in Bergen, Norway. "These blood tests could provide a low-cost alternative to MRI for monitoring disease activity."
Study conducted on patients with relapsing-remitting MSRelapsing-remitting MS (RRMS) is a form of MS where patients experience flare-ups of their neurological symptoms followed by periods of no disease progression or remission.
Study designEighty five patients with RRMS were monitored for an average period of two years.
Magnetic resonance imaging (MRI): MRI scans were performed every month for the first nine months, after which, two scans were done, one at year one and the other at year two. The frequent MRI scans are a limitation of the study.
Blood tests: Blood samples were taken at the beginning of the study, at three months, six months, year one and year two.
Results of the studyThe neurofilament light chain (NfL) levels were monitored during the two years and their blood levels were found to be higher (and present for a three-month time period) when the MRI detected new disease activity (characterized by T1 and T2 lesions in the brain that are known to occur due to MS).
NfL blood levels were lower in patients when interferon beta 1a treatment was taken to reduce flare-ups.
Statistical results include:
- Level of NfL detected was 37.3 picograms per milliliter (pg/ml) when T1 lesions were present compared with 28 pg/ml for people without new T1 lesions.
- Level of NfL detected was 37.3 picograms per milliliter (pg/ml) when T2 lesions were present compared with 27.7 pg/ml for people without new T2 lesions.
- An increase of 10 pg/ml in a person was associated with a 48-percent increased risk of developing a new T1 lesion and 62-percent increased risk of developing a new T2 lesion.
ConclusionThe findings suggest that measuring the levels of NfL in the blood may be an effective way to monitor disease activity and to ascertain the effectiveness of treatment. Future studies may need to be done with extended follow-up times.
Multiple sclerosis (MS)Multiple sclerosis (MS) is a brain disorder in which the protective layer that covers the brain and spinal cord known as the myelin sheath is damaged. This leads to improper signalling of nerve messages in some parts of the brain. It mostly affects people in the age group between 20 and 50 and is more common in women. It is considered to be an immune-mediated process because the exact antigen or target that makes the immune system direct its action against the central nervous system (CNS is unknown.
MS is known to surface in genetically predisposed people when there are exposed to certain environmental triggers. The patients experience one of four disease courses among which the relapsing-remitting MS (RRMS) is the most common course (85% of people with MS are initially diagnosed with RRMS).
In RRMS, there are clear defined attacks of new or increasing neurologic symptoms that are called relapses or exacerbations. These relapses are followed by partial or complete recovery periods or remissions. While in remission periods, symptoms may disappear, continue or become permanent but there is no apparent disease progression that takes place.
- Kristin N. Varhaug, Christian Barro, Kjetil Bjørnevik, Kjell-Morten Myhr, Øivind Torkildsen, Stig Wergeland, Laurence A. Bindoff, Jens Kuhle, Christian Vedeler. Neurofilament light chain predicts disease activity in relapsing-remitting MS. Neurology - Neuroimmunology Neuroinflammation, 2017; 5 (1): e422 DOI: 10.1212/NXI.0000000000000422
- Multiple Sclerosis News & Research - (https://www.nationalmssociety.org/)