Routine use of paracetamol after vaccination in infants cannot be recommended, suggests studies. Acetaminophen (or paracetamol) is the most common medication used for fever in children. It is an effective and safe drug when used in its normal dosage. Some children experience high temperature or fever following vaccination. This fever very rarely reaches proportions where it could cause complications like seizures. However, it could cause discomfort and disruption of sleep in the child as well as her parents. Parents may have to miss work to take care of the child. The fever may also introduce doubts in the minds of the parents regarding the safety of immunizations. Should acetaminophen be administered to infants routinely after immunization to prevent fever? Researchers conducted a study in Washington to find an answer to this question. 352 infants less than 10 months of age were included in the study. They were administered either acetaminophen or an inert substance called placebo that was similar in appearance to acetaminophen. The parents were not aware which preparation the child was administered. The researchers found that infants that received acetaminophen were less likely to have fever compared to those that did not receive this medicine, though this difference was not significant. They were also less likely to be fussy post vaccination. Thus acetaminophen given to prevent fever appears to be beneficial. High fever was reported in only 3 infants who did not receive acetaminophen and febrile seizures were not reported in any infant in the study. Thus, none of the infants that did not receive acetaminophen have serious fever-related complications. Another similar study, however, indicated that routine use of acetaminophen with vaccines could decrease the immune response to vaccination and thereby reduce its benefits. The researchers thus concluded that although use of acetaminophen to prevent fever in infants post vaccination helps to control their temperature and reduce fussiness, it could interfere with the immune response elicited by the vaccines. Also, fever post vaccination very rarely reaches dangerous proportions. Thus, its routine use in this situation cannot be recommended currently. Reference : 1. Jackson LA, Peterson D, Dunn J, Hambidge SJ, Dunstan M, Starkovich P, Yu O, Benoit J, Dominguez-Islas CP, Carste B, Benson P, Nelson JC. A Randomized Placebo-Controlled Trial of Acetaminophen for Prevention of Post-Vaccination Fever in Infants. PLoS One. 2011; 6(6): e20102.Source: Medindia << Air Pollution and Cancer Incidence: a Danish Cohort Study Eat Well Otherwise the Brain Will Start Eating Itself! >> Recommended Reading Febrile Fits / Febrile Convulsions High fever in kids can cause convulsions and are called febrile fits that do not include the seizures that occur as a result of brain infection. READ MORE Clinical approach to a child with fever A good clinical history and a thorough physical examination should form the basis of making a provisional diagnosis. Laboratory tests should be supportive. READ MORE Fever - First Aid and Emergency Treatment Guide Fever also called as pyrexia is higher-than-normal body temperature. A quick and simple First Aid guide on how to administer treatment for Fever. READ MORE Top 10 Vaccine Myths Debunked Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and eliminate myths regarding vaccines. READ MORE Traveling with Children Abroad? - Parents, Stay Alert! Traveling with children is always challenging as it involves careful planning. Here are some precautions that need to be taken when traveling abroad with kids. READ MORE Most Popular on Medindia Sanatogen Vent Forte (Theophylline) Blood Pressure Calculator More News on: Top 10 Vaccine Myths DebunkedTraveling with Children Abroad? - Parents, Stay Alert!