Multiple Sclerosis (MS) Does Not Worsen Following Pregnancy

Multiple Sclerosis (MS) Does Not Worsen Following Pregnancy

  • Post pregnancy period does not increase the risk of relapse of multiple sclerosis or cause a deterioration in the condition as currently believed according to this latest study
  • Most patients have the relapsing and remitting form of the disease where the symptoms settle down for a period and then suddenly flare up. The condition is common in women in the reproductive age
  • Women can safely undergo pregnancy, breastfeed their babies and resume treatment after delivery without increased risk of worsening of symptoms and deterioration

Women diagnosed with multiple sclerosis need not worry about the risk of worsening of the condition or a flare-up immediately after pregnancy, according to the findings of a recent study at Kaiser Permanente Southern California in Pasadena.

The findings of the study will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia.

Multiple Sclerosis (MS) Does Not Worsen Following Pregnancy

Annette Langer-Gould, MD, Ph.D., of Kaiser Permanente, the study author said: "These results are exciting, as MS is more common among women of childbearing age than in any other group. This shows us that women with MS today can have children, breastfeed and resume their treatment without experiencing an increased risk of relapses during the postpartum period."

Does Childbirth Increase Risk of Multiple Sclerosis Relapse

Until now it was believed that multiple sclerosis symptoms deteriorate after childbirth. The study team hoped to determine if this information that was put forth 20 years ago is still valid in the modern scenario where disease-modifying treatments have become available and MRI scans can diagnose multiple sclerosis in the very early stages before it can progress.
  • The study team went through all patient records from Kaiser Permanente Southern and Northern California databases and found 375 women with MS accounting for 466 pregnancies from 2008 to 2016.
  • They surveyed the women for more information about treatment history, pregnancy details, breastfeeding and episodes of remission and relapse
  • Of the 375 women, 38 percent reported not receiving any treatment for MS in the year prior to becoming pregnant.
  • A total of 15 percent just had the clinically isolated syndrome, which is the first occurrence of MS symptoms when they became pregnant
  • A small proportion of the women (8%) had a relapse during pregnancy.
  • Following delivery, 26 percent of the women had a flare-up, 87 percent breastfed their babies of which 35 percent breastfed exclusively.
  • 41 percent of participants resumed taking their disease-modifying treatments after delivery
  • Before pregnancy, the yearly relapse rate was 0.39, which fell to 0.07 to 0.14 during pregnancy.
  • After birth, the symptoms did not worsen more, showing a rate in the first three months after the birth of 0.27, slightly less than pre-pregnancy relapse rates
  • By four to six months after delivery, the relapse rate had returned to the pre-pregnancy baseline level of 0.37
The results remained the same even after the scientists adjusted for other influencing factors that could affect the relapse rate, including the severity of the symptoms before pregnancy.

Interestingly, breastfeeding the baby appeared to be beneficial in reducing the risk of Multiple Sclerosis relapse.
  • Women who breastfed their babies on their milk exclusively for the first two months had a 40% lower risk of relapse compared to women who did not breastfeed.
  • Of the 167 women who breastfed exclusively, 67 resumed disease-modifying agents while they were breastfeeding
  • Restarting moderately effective disease-modifying agents such as interferon-betas and glatiramer acetate did not influence the rate of relapse
  • Women who gave formula in addition to breast milk within two months after delivery appeared to have a similar risk of relapse as women who never breastfed
The findings of the study indicate that childbirth does not increase the risk of relapse of multiple sclerosis. According to the author, the lower rates of relapse following childbirth in this study could be due to the inclusion of women who just had one isolated episode as well as a high proportion of women who exclusively breastfed.

Future Plans

Further studies need to be conducted to further analyze the subgroup of women with severe relapses related to cessation of treatment such as natalizumab or fingolimod that they were taking prior to pregnancy.


The period immediately after delivery in women with multiple sclerosis does not increase the risk of relapse of the condition. Women with MS can have babies, breastfeed them and restart their medications after childbirth.

Reference :
  1. Good news for women with ms: Disease may not worsen after pregnancy after all - (

Source: Medindia

News A-Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Trimester of pregnancy Pregnancy and Exercise Home Pregnancy Test Pregnancy Psychological Changes In Pregnancy Drugs in Pregnancy and Lactation Breech Presentation and Delivery Air travel: To fly or not to fly Chemotherapy Chemotherapy Drugs 

Recommended Reading
Possible Mechanism for Protective Effect of Testosterone in Multiple Sclerosis Uncovered
The protective mechanism of testosterone in multiple sclerosis has been suggested to be due to the ....
Can Breastfeeding Reduce The Risk of Developing Multiple Sclerosis?
Mothers, especially those who breastfeed for at least 15 months or more, were found to be less ......
Pregnant Women With Multiple Sclerosis Less Likely to Suffer Complications
A new study has revealed that pregnant women with multiple sclerosis are at a modest risk of ......
Multiple Sclerosis - Famous Personalities
Multiple sclerosis affects more females than males and it is estimated that there are over a ......
Air travel: To fly or not to fly
Air travel is for everyone, even those with medical conditions....
Breech Presentation and Delivery
Breech birth or presentation is delivery of the fetus in a bottom or foot-first position. Causes of ...
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Drugs in Pregnancy and Lactation
During pregnancy & lactation a nutritious diet, suitable exercise, adequate rest and a tranquil mind...
Home Pregnancy Test
A home pregnancy test is a test done to find out if one is pregnant or not in the relative comforts ...
Detailed look at Early pregnancy Symptoms and easy health solutions during 1st, 2nd and 3rd trimeste...
Psychological Changes In Pregnancy
Pregnancy is an experience of growth, change, enrichment and challenge. During the 40 weeks of pregn...
Trimester of pregnancy
Encyclopedia section of medindia explains in brief about confirmation of pregnancy in first ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use