Acute myocardial infarction or heart attack is a life-threatening condition that occurs when blood flow to the heart is abruptly cut off, causing tissue damage.
Researchers delivered human stem cells seeded in biological sutures
to the damaged heart muscles of rats following induced acute myocardial
infarction and assessed the effects on cardiac function one week later.
‘There were changes in heart function directly in the region where scientists delivered the stem cells in heart muscle after heart attack.’
The differences in mechanical function at a local and global level when
stem cell seeded sutures were used compared to sutures without stem
cells are reported in an article in BioResearch Open Access
. The article is available on the BioResearch Open Access
The study entitled "Functional effects of Delivering Human Mesenchymal Stem Cell Seeded Biological Sutures to an Infarcted Heart"
is coauthored by Katrina Hansen, Glenn Gaudette and colleagues from
Worcester Polytechnic Institute (Worcester, MA), Massachusetts General
Hospital (Boston, MA), and University of Arkansas for Medical Sciences
(Little Rock, AR).
The researchers demonstrate changes in heart function
that occur directly in the region where they delivered the stem cells.
These regional functional changes were not evident with the use of
non-cell seeded sutures. The authors describe how varying the
concentration of stem cells used to seed the sutures and the timing of
seeding affected that amount of cells seeded onto the sutures.
"This study addresses an important issue in cell therapeutics: how to deliver the cells to a specific target," says BioResearch Open Access
Editor Jane Taylor, Edinburgh Medical School: Biomedical Sciences,
University of Edinburgh, Scotland. "Although cardiac repair was the
goal here, this work has potential applications for a whole range of
other cell types and tissues."