Scientists for the first time have developed a vaccine for gut bacteria common in autistic children that may help control some autism symptoms.
Brittany Pequegnat and Guelph chemistry professor Mario Monteiro developed a carbohydrate-based vaccine against the gut bug Clostridium bolteae.
Autism
Autism is a neurodevelopmental disorder typically characterized by impaired social and communication skills combined with repetitive movements.
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C. bolteae is known to play a role in gastrointestinal disorders, and it often shows up in higher numbers in the GI tracts of autistic children than in those of healthy kids.
More than 90 percent of children with autism spectrum disorders suffer from chronic, severe gastrointestinal symptoms. Of those, about 75 percent suffer from diarrhea, according to current literature.
![Quiz on Autism]( "Quiz on Autism")
Introduction Autism spectrum disorder is a complex genetic disorder that impairs social, behavioral, and communication functions in humans. Autistic people may act, communicate, interact, and learn differently than most other people. ASD usually begins in childhood and can last for the rest of a person's life, though symptoms may improve over time . This quiz on ' Autism
"Little is known about the factors that predispose autistic children to C. bolteae," said Monteiro.
Although most infections are handled by some antibiotics, he said, a vaccine would improve current treatment.
"This is the first vaccine designed to control constipation and diarrhea caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe," he said.
Autism cases have increased almost six fold over the past 20 years, and scientists don't know why. Although many experts point to environmental factors, others have focused on the human gut.
Some researchers believe toxins and/or metabolites produced by gut bacteria, including C. bolteae, may be associated with symptoms and severity of autism, especially regressive autism.
Pequegnat, a master's student, and Monteiro used bacteria grown by Mike Toh, a Guelph PhD student in the lab of microbiology professor Emma Allen-Vercoe.
The new anti- C. bolteae vaccine targets the specific complex polysaccharides, or carbohydrates, on the surface of the bug.
The vaccine effectively raised C. bolteae-specific antibodies in rabbits. Doctors could also use the vaccine-induced antibodies to quickly detect the bug in a clinical setting, said Monteiro.
The vaccine might take more than 10 years to work through preclinical and human trials, and it may take even longer before a drug is ready for market, Monteiro said.
But this is a significant first step in the design of a multivalent vaccine against several autism-related gut bacteria, he said.
The groundbreaking study appeared this month in the journal Vaccine.
Source: ANI
Quiz on Autism
Introduction Autism spectrum disorder is a complex genetic disorder that impairs social, behavioral, and communication functions in humans. Autistic people may act, communicate, interact, and learn differently than most other people. ASD usually begins in childhood and can last for the rest of a person's life, though symptoms may improve over time . This quiz on ' Autism
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"Little is known about the factors that predispose autistic children to C. bolteae," said Monteiro.
Although most infections are handled by some antibiotics, he said, a vaccine would improve current treatment.
"This is the first vaccine designed to control constipation and diarrhea caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe," he said.
Autism cases have increased almost six fold over the past 20 years, and scientists don't know why. Although many experts point to environmental factors, others have focused on the human gut.
Some researchers believe toxins and/or metabolites produced by gut bacteria, including C. bolteae, may be associated with symptoms and severity of autism, especially regressive autism.
Pequegnat, a master's student, and Monteiro used bacteria grown by Mike Toh, a Guelph PhD student in the lab of microbiology professor Emma Allen-Vercoe.
The new anti- C. bolteae vaccine targets the specific complex polysaccharides, or carbohydrates, on the surface of the bug.
The vaccine effectively raised C. bolteae-specific antibodies in rabbits. Doctors could also use the vaccine-induced antibodies to quickly detect the bug in a clinical setting, said Monteiro.
The vaccine might take more than 10 years to work through preclinical and human trials, and it may take even longer before a drug is ready for market, Monteiro said.
But this is a significant first step in the design of a multivalent vaccine against several autism-related gut bacteria, he said.
The groundbreaking study appeared this month in the journal Vaccine.
Source: ANI
Placenta Helps Predict Autism Risk
An infant's risk of developing autism can be measured by looking for abnormalities in his/her placenta at birth, say researchers.
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 Autism in Mice Linked With Abnormalities in Genes Associated With Brain DevelopmentA new study conducted by American researchers on a group of mice has linked autism with abnormalities in specific regions of their chromosomes in genes associated with aberrant brain development. | Advertisement
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