About My Health Careers Internship MedBlogs Contact us

Fetal Damage Assured If Zika Virus Infection Follows Dengue During Pregnancy

by Rishika Gupta on February 10, 2019 at 6:29 PM
Font : A-A+

Fetal Damage Assured If Zika Virus Infection Follows Dengue During Pregnancy

Women who have previously been infected with dengue virus could be at an increased risk of causing damage to their unborn baby and placenta if they later become infected with the Zika virus. The results of this study are published in the journal of Immunity.

Prior Dengue virus infection may cause severe outcomes following Zika virus infection during pregnancy; Mount Sinai study shows.


Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report.

This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model.

Results of the study, "Dengue virus immunity increases Zika virus-induced damage during pregnancy," were published in the February issue of Immunity, a journal published by Cell Press.

Zika virus outbreaks were first found to be associated with birth defects including microcephaly, in which the baby is born with an abnormally small head and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic. The research team led by Jean Lim, Ph.D., Associate Professor of Microbiology and Co-Director of Microbiology Multidisciplinary Training in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, transferred dengue virus-specific antibodies into mice prior to infection with Zika virus during pregnancy. The presence of these antibodies in the mice significantly increased placental damage, fetal growth, and fetal resorption. Zika-infected human placental tissues also showed increased replication in the presence of dengue antibodies.

"Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy," said Dr. Lim. "Our research may explain the high rate of microcephaly and congenital disabilities observed in the recent Zika virus outbreak in South America."

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chicken Pox Dengue Fever Trimester of pregnancy Pregnancy and Exercise Home Pregnancy Test Pregnancy Dengue / Dengue Hemorrhagic Fever Mosquito Diseases Psychological Changes In Pregnancy Shigellosis 

Recommended Reading
Zika Virus Infection in Mother can Cause Brain Damage in Fetus
Women affected with Zika virus during pregnancy can cause dementia, learning disorders, and ......
Zika Virus Infection Associated With Guillain-Barré Syndrome
Guillain-Barré syndrome is an uncommon autoimmune disorder characterized by progressive weakness ......
Cocktail of Monoclonal Antibodies Prevents Zika Virus Infection
A mixture of three potent monoclonal antibodies were completely able to block Zika virus infection ....
Infants Exposed to Zika Virus Infection in Pregnancy Should Have Eyes Examined
Eye abnormalities in infants from Brazil born to mothers with confirmed Zika virus infection in ......
Chicken Pox
Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus....
Dengue / Dengue Hemorrhagic Fever
Encyclopedia section of medindia gives general information about Dengue and Dengue Hemorrhagic ......
Home Pregnancy Test
A home pregnancy test is a test done to find out if one is pregnant or not in the relative comforts ...
Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosqu...
Detailed look at Early pregnancy Symptoms and easy health solutions during 1st, 2nd and 3rd trimeste...
Psychological Changes In Pregnancy
Pregnancy is an experience of growth, change, enrichment and challenge. During the 40 weeks of pregn...
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...
Trimester of pregnancy
Encyclopedia section of medindia explains in brief about confirmation of pregnancy in first ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use