About Careers MedBlog Contact us

Exposure to Cold Increases Levels of Zfp516 Protein Which Helps Lose Weight

by Dr. Trupti Shirole on January 10, 2015 at 2:54 AM
Font : A-A+

 Exposure to Cold Increases Levels of Zfp516 Protein Which Helps Lose Weight

Exposure to cold temperatures increases levels of a newly discovered protein, called transcription factor Zfp516, which is critical for the formation of brown fat, the type of fat in our bodies that generates heat, according to researchers at the University of California, Berkeley. Researchers also found that with extended exposure to chilly air, Zfp516 protein also helps the more abundant white fat in our bodies, the kind that stores excess energy, become more similar to brown fat in its ability to burn energy.

Brown fat has relatively high levels of mitochondria, the cell's power station. In humans, brown fat was thought to be present only in infants, but stores of it were recently discovered in adults around vital organs like the heart, brain, neck and spinal cord.


Mice studies revealed that rodents with boosted levels of the Zfp516 protein gained 30 percent less weight than control mice when both groups were fed a high-fat diet.

Hei Sook Sul, UC Berkeley professor of nutritional science and toxicology, said, "Knowing which proteins regulate brown fat is significant because brown fat is not only important for thermogenesis, but there is evidence that brown fat may also affect metabolism and insulin resistance. If one can somehow increase levels of this protein through drugs, they could have more brown fat, and could possibly lose more weight even if eating the same amount of food."

The study appears online in the journal Molecular Cell.

Source: Medindia


Recommended Reading

Latest Research News

New Biomarkers Help Detect Alzheimer's Disease Early
A group of scientists were awarded £1.3 million to create a new “point of care testing” kit that detects Alzheimer's disease biomarkers.
 Bone Health and Dementia: Establishing a Link
Is there a connection between Osteoporosis and dementia? Yes, loss in bone density may be linked to an increased risk of dementia in older age.
Is Telomere Shortening a Sign of Cellular Aging?
Link between chromosome length and biological aging marker discovered. The finding helps explain why people with longer telomeres have a lower dementia risk.
Why Is Integrated Structural Biology Important for Cystic Fibrosis?
Integrated structural biology helps discover how the cystic fibrosis transmembrane conductance regulator (CFTR) works.
Impact of Age-Related Methylation Changes on Human Sperm Epigenome
Link between advanced paternal age and higher risks for reproductive and offspring medical problems has been discovered.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Exposure to Cold Increases Levels of Zfp516 Protein Which Helps Lose Weight Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests