Hospitalization rates for chronic obstructive pulmonary disease (COPD) are continuing to increase and a majority of asthma patients live with significant symptoms, impairing their quality of life. While the labels of asthma and COPD are valuable for patients who display stereotypical symptoms, there are a growing number of patients who do not fit this category, including patients with adult-onset asthma, smoking asthmatics, or patients with the so-called asthma-COPD overlap syndrome.
Defining a patient's symptoms using the historical diagnostic labels of asthma and COPD is an outdated approach to understanding an individual's condition, suggested experts writing in the European Respiratory Journal.
In a perspective article, Professor Alvar Agusti and colleagues call for a new approach to patient management, which moves away from categorizing patients using the broad disease terms of asthma and COPD and towards a more personalized approach to management that identifies 'treatable traits' in each patient.
Professor Agusti commented, "We propose a label-free precision medicine approach based on treatable traits that categorize the clinical and biological complexity of airway disease. The approach we are suggesting would radicalize healthcare and have significant implications for the organisation of a healthcare system. By recognizing the clinical and biological complexity of a disease, we can use causal mechanistic disease pathways to adopt a more precise approach, which is hopefully more effective at managing patients with these conditions."
In an accompanying editorial, Professor Peter Sterk, from the University of Amsterdam, supports the call for a move away from diagnostic labels. Professor Sterk commented, "We are living in an era where we have new biological knowledge and new targets for therapy but we largely continue to guide patient management with diagnostic labels. It is the right time for healthcare professionals to take bold steps and move aware from historical diagnoses that are impeding modern medicine."