Inhaled doses of as small as 2 mg of the synthetic cannabinoid JWH-018 can significantly reduce critical thinking and memory, slow response times, and raise confusion and dissociation reports a new study. The findings of the study are published in the journal Cannabis and Cannabinoid Research.
Seventeen healthy participants inhaled the vapor of JWH-018 in doses ranging from 2-6.2 mg.
The article entitled "Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders" describes the highly variable subjective intoxication of the participants.
"This is incredibly important as it is the first controlled human laboratory study of synthetic cannabinoids that have been found in illicit drug products such as Spice and K2," says Associate Editor Dr. Ryan Vandrey, John Hopkins School of Medicine.
"Demonstrating safety and providing initial dose-effects on key outcomes will hopefully inspire additional research in this area."