Undernutrition in Pregnancy Changes Lung-Specific Gene Expressions

by Mohamed Fathima S on  March 20, 2019 at 11:32 AM Diet & Nutrition News
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A range of health problems including cardiovascular disease and asthma were seen in children of mothers who were pregnant during the Dutch famine, finds new research. Epigenetic markers in offspring could be affected by the mother's diet, and this causes changes in the genes that regulate lung health. However, the exact mechanisms behind this epigenetic inheritance have not been fully explored.
Undernutrition in Pregnancy Changes Lung-Specific Gene Expressions
Undernutrition in Pregnancy Changes Lung-Specific Gene Expressions

"The findings paint a clearer picture of how a mother's nutrition and environment can affect her child's health," says senior author pulmonologist Jesse Roman, MD, Professor and CEO of the Jane & Leonard Korman Respiratory Institute - Jefferson Health and National Jewish Health. "Epigenetic mechanisms are powerful in biology and we're really still scratching the surface in trying to understand them." The research was published in the journal Nutrition Research.

Epigenetic changes may allow for a mother's experiences to be passed to the offspring. Genetically, it's not possible for mutations in skin or liver cells acquired over the course of a lifetime to be passed to a child. Children get a clean genetic slate. But, epigenetic changes can be passed down.

If a person's genome is a set of blueprints or plans for building an organism, then a genetic mutation would be penciling in a new wall, or erasing a floor from those plans. Rather than change the blueprint, epigenetic changes leave the blueprint intact, but instead, roll up a page into a tight and inaccessible bundle. The plans, or genes, on those rolled pages, can't be read by the cell's architects. Other types of epigenetic changes prevent pages from getting rolled at all, causing many more of that architectural element, or protein, to be made than needed.

When Dr. Roman, together with first author Igor Zelko, PhD, from the University of Louisville, Kentucky and colleagues, examined the lung-related genes in offspring of mice whose diet was limited during the second and third trimesters of gestation, they saw that a handful of them had a different expression level than mice who ate freely.

In particular, the expression of two genes were turned up via epigenetic mechanisms that in this case, kept the blueprint open longer than needed, producing more of that protein. The researchers found higher levels of fibronectin in mice born to malnourished mothers. Fibronectin is a connective tissue molecule that provides a substrate on which cells can organize. However, its fragments may attract neutrophils, an immune cell that can exacerbate inflammatory reactions, like asthma. Expression of the Selplg gene was also turned up. Higher levels of Selplg may predispose blood vessels to inflammation as well as clotting.

"The work represents a first step in understanding how gene expression is affected by the environment. In this case, malnutrition resulted in changes in gene expression through epigenetic changes that could be potentially transferred down through the generations," says Dr. Roman. "The next steps would be to understand how these genes might affect lung function in these offspring and what other factors can influence these events."



Source: Eurekalert

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