Effect of Treadmill Exercise Training for Multiple Sclerosis

Treadmill walking exercise training may be an effective approach to managing the debilitating cognitive effects of the disease, according to a pilot study by a team of multiple sclerosis (MS) researchers.

In this study, 11 ambulatory individuals with relapsing-remitting MS were randomized to either 12-weeks of supervised treadmill walking exercise (intervention group), or 12 weeks of low-intensity resistive exercise (control group).

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‘Treadmill exercise training shows promise for managing the cognitive effects of multiple sclerosis.’

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All participants underwent neuropsychological tests of learning and memory and hippocampal neuroimaging before and after their 12-weeks of exercise.

Researchers saw improvements in verbal learning and memory in the intervention group and preservation of hippocampal volume. Non-significant effects were found on functional connectivity.

These results provide initial proof-of-concept data for the use of treadmill training for walking exercise as a possible behavioral approach for managing the deleterious effects of MS on learning and memory.

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“This study is an important first step in the development of an intervention targeted at the specific cognitive domains affected by MS,” said Dr. Brian Sandroff, Ph.D., a senior research scientist in the Center for Neuropsychology and Neuroscience Research at Kessler Foundation.

Showing efficacy for low-cost, non-invasive, widely available interventions will help us manage the effects of MS, supporting individuals striving to maintain their participation at home, at work, and in their communities.

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To pursue the findings, larger-scale studies are needed to explore the relationships between exercise training and functional and structural changes in the brain, and the optimal protocols for clinical implementation.

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Source-Medindia