About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Early Pregnancy Reduces Risk of Breast Cancer

by Sheela Philomena on May 1, 2013 at 12:33 PM
Font : A-A+

 Early Pregnancy Reduces Risk of Breast Cancer

Getting pregnant at a young age is known to protect a woman against breast cancer, suggests study.

Researchers in BioMed Central found that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

Advertisement

In humans having a child before the age of 20 decreases risk of breast cancer by half.

Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.
Advertisement

The activity of one particular gene Wnt4 was also down-regulated after pregnancy.

The protein from this gene (Wnt4) is a feminising protein - absence of this protein propels a foetus towards developing as a boy.

Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.

Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy.

Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study said, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."

The research is published in the open access journal Breast Cancer Research.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Trimester of pregnancy Pregnancy and Exercise Home Pregnancy Test Pregnancy Pagets disease of the breast Mastitis Psychological Changes In Pregnancy Cancer and Homeopathy 

Recommended Reading
Pregnancy
Detailed look at Early pregnancy Symptoms and easy health solutions during 1st, 2nd and 3rd ......
Quiz on Breast Cancer
Breast cancer is one of the leading causes of cancer deaths among women. It is often said that a ......
Multiple Pregnancy Calculator
Multiple Pregnancy Calculator assesses your pregnancy symptoms and finds if you are pregnant with .....
Breast Self Examination - Animation
Slides and animation of Breast Self Examination for early detection of breast cancer lumps in ......
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Home Pregnancy Test
A home pregnancy test is a test done to find out if one is pregnant or not in the relative comforts ...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Psychological Changes In Pregnancy
Pregnancy is an experience of growth, change, enrichment and challenge. During the 40 weeks of pregn...
Trimester of pregnancy
Encyclopedia section of medindia explains in brief about confirmation of pregnancy in first ......
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use