Bladder cancer could be diagnosed early and be identified at its treatable stages, scientists have discovered, by testing to see if microRNA is present or absent.
"Measuring expressions of microRNA in bodily fluid represents a very promising tool with widespread implications for screening," said Liana Adam, M.D., Ph.D., assistant professor in urology at The University of Texas MD Anderson Cancer Center.
Adam presented her findings at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.
Scientists are working with microRNAs, the non-coding part of DNA, because they are often tissue specific, stable and their presence or absence can be linked to known clinical parameters.
In this case, Adam and colleagues identified 79 separate microRNAs that had been previously shown to be dysregulated in the blood of individuals with bladder cancer. They took blood samples from 20 individuals with preoperative bladder cancer and 18 in a control group.
Using a collection of standard statistical models, they determined that measurement of these microRNAs was as accurate as the current gold standard of testing.
"This needs further validation, but we could reasonably use this method for widespread screening of bladder cancer," said Adam.