About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Disrupted Connections in the Brains of Young People With ADHD Shown in MRI

by Dr. Enozia Vakil on April 30, 2014 at 9:21 PM
Font : A-A+

 Disrupted Connections in the Brains of Young People With ADHD Shown in MRI

Disrupted connections between different areas of brain of the children and adolescents with attention deficit hyperactivity disorder (ADHD) is evident on resting state functional (MRI). The results of this research are published online in the journal Radiology.

The findings point to the potential of rfMRI to help provide objectively accurate, early diagnosis of a disorder that affects approximately 5 percent of children and adolescents worldwide.

Advertisement

ADHD is a disorder characterized by age-inappropriate degrees of inattention, hyperactivity and impulsivity. Functional MRI studies, which measure brain activity when a person is focused on a particular task, have implicated the brain's frontostriatal circuit, a collection of neural pathways in the frontal lobe of the brain that helps control behavior. However, the specific brain physiology underlying ADHD remains poorly understood.

For the new study, researchers used rfMRI, a relatively new technique that assesses neural function when the brain is not focused on a specific task. The technique is useful for exploring the brain's functional organization independent of task performance.
Advertisement

The researchers compared rfMRI results in 33 boys with ADHD, ages 6 to 16, with those of 32 similarly aged, healthy controls. They correlated the MRI findings with results from tests of executive function, a term for the set of mental processes involved in planning, organizing, time management and regulating emotions, among other things. People with ADHD often have abnormal executive function.

The results showed that the patients with ADHD had altered structure and function located in areas of the brain like the orbitofrontal cortex, which is primarily involved in the cognitive processing of strategic planning, and the globus pallidus, which is involved in executive inhibitory control.

"Our study suggests that the structural and functional abnormalities in these brain regions might cause the inattention and hyperactivity of the patients with ADHD, and we are doing further analysis on their correlation with the clinical symptoms," said Qiyong Gong, M.D., Ph.D., a neuroradiologist from the Department of Radiology at West China Hospital of Sichuan University in Sichuan, China. "Our preliminary results show the association between imaging findings and symptoms."

The researchers also found abnormalities in the connections between resting-state brain networks associated with executive dysfunction. These abnormalities indicate more widespread brain alterations in ADHD than previously had been shown, Dr. Gong said.

Exploration of the association between brain activity and executive function might be useful in better characterizing patients with ADHD and in understanding the pathophysiology underlying the condition, according to Dr. Gong.

"Our results suggest the potential clinical utility of the rfMRI changes as a useful marker, which may help in diagnosis and in monitoring disease progression and, consequently, may inform timely clinical intervention in the future," he said.

Dr. Gong indicated that larger studies are needed to validate the results. The researchers also plan to study changes in connectivity over time in ADHD patients and explore the potential differences of functional connectivity between the clinical subtypes of ADHD, such as inattentiveness and hyperactivity.

The ADHD study is part of a larger project from Dr. Gong's group at Huaxi MR Research Center of the West China Hospital to explore MRI's diagnostic and prognostic potential in psychiatric disorders.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Dyslexia Attention Deficit Hyperactivity Disorder (ADHD) Magnetic Resonance Imaging Bullying at School - Tips For Schools ADHD Dyscalculia / Learning Disabilities Hearing Loss Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) Diet to control Attention Deficit Hyperactivity Disorder 

Recommended Reading
Antipsychotic Drug Use Among Youth With ADHD is Increasing
Antipsychotic medicines are often used for unlabeled indications, such as treatment of kids and ......
Research Reveals Genetic Predisposition to Liking Amphetamine Reduces Risk of Schizophrenia and ADHD
New research suggests that genetic variants associated with enjoying the effects of d-amphetamine .....
Increased Gender Variance in Children With Autism and ADHD Reported in Study
Children with autism spectrum disorders or attention deficit hyperactivity disorder were more ......
Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder that affects normal be...
Diet to control Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that affects children of ...
Dyscalculia / Learning Disabilities
Dyscalculia is a learning disability involving mathematics. Recognized by The WHO, it affects nearl...
Dyslexia
Dyslexia is a reading disability that occurs when the brain does not properly recognize and process ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Magnetic Resonance Imaging
Encyclopedia section of medindia gives general info about Magnetic Resonance Imaging...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use