About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Study Sheds Light on Sports-related Brain Injuries

by Dr. Enozia Vakil on April 30, 2014 at 9:20 PM
Font : A-A+

 New Study Sheds Light on Sports-related Brain Injuries

Repeated blows to the head causes the behavioral damage according to a new study.

The research - which appears online this week in the Journal of Neurotrauma - shows that mice with mild, repetitive traumatic brain injury (TBI) develop many of the same behavioral problems, such as difficultly sleeping, memory problems, depression, judgment and risk-taking issues, that have been associated with the condition in humans.

Advertisement

One of the barriers to potential treatments for TBI and CTE is that no model of the disease exists. Animal equivalents of human diseases are a critical early-stage tool in the scientific process of understanding a condition, developing new ways to diagnose it, and evaluating experimental therapies.

"This new model captures both the clinical aspects of repetitive mild TBI and CTE," said Anthony L. Petraglia, M.D., a neurosurgeon with the University of Rochester School of Medicine and Dentistry and lead author of the study. "While public awareness of the long-term health risk of blows to the head is growing rapidly, our ability to scientifically study the fundamental neurological impact of mild brain injuries has lagged."
Advertisement

There has been a great deal of discussion in recent years regarding concussions as a result of blows to the head in sports. An estimated 3.8 million sports-related concussions occur every year. Mild traumatic brain injury is also becoming more common in military personnel deployed in combat zones. Over time, the frequency and degree of these injuries can lead short and long-term neurological impairment and, in extreme examples, to CTE, a form of degenerative brain disease.

The experiments described in the study were designed in a manner that simulates the type of mild TBI that may occur in sports or other blows to the head. The researchers evaluated the mice's performance in a series of tasks designed to measure behavior. These included tests to measure spatial and learning memory, anxiety and risk-taking behavior, the presence of depression-like behavior, sleep disturbances, and the electrical activity of their brain. The mice with repetitive mild TBI did poorly in every test and this poor performance persisted over time.

"These results resemble the spectrum of neuro-behavioral problems that have been reported and observed in individuals who have sustained multiple mild TBI and those who were subsequently diagnosed with CTE, including behaviors such as poor judgment, risk taking, and depression," said Petraglia.

Petraglia and his colleagues also used the model to examine the damage that was occurring in the brains of the mice over time. The results, which will be published in a forthcoming paper, provide insight on the interaction between the brains repair mechanisms - in the forms of astrocytes and microglia - and the protein tau, which can have a toxic effect when triggered by mild traumatic brain injury.

"Undoubtedly further work is needed," said Petraglia. "However, this study serves as a good starting point and it is hoped that with continued investigation this novel model will allow for a controlled, mechanistic analysis of repetitive mild TBI and CTE in the future, because it is the first to encapsulate the spectrum of this human phenomenon."



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Research News

What Are the Effects of Smoking on Quality of Life?
Tobacco smoke contains toxic chemicals which damage lungs, weaken the immune system and cause tuberculosis.
 Brain Shape Controls Our Thoughts, Feelings, and Behaviour
Identifying an unappreciated relationship between brain shape and activity overturns the century-old paradigm emphasizing the importance of complex brain connectivity.
Eight Threats to Black Adult's Longevity
Decoding the eight factors affecting Black adults' life expectancy.
Beyond the Campus: Contrasting Realities Revealed!
Sobering truth about foot travel in the United States emerges from international statistics, highlighting the prevalence of walking on the Blacksburg campus.
Astounding Link Between Darwin's Theory and Synaptic Plasticity — Discovered!
Unveiling a hidden mechanism, proteins within brain cells exhibit newfound abilities at synapses, reinforcing Darwin's theory of adaptation and diversity in the natural world.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

New Study Sheds Light on Sports-related Brain Injuries Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests