About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Diagnose Asthma more Accurately with a New Test

by Sam John Xavier on December 23, 2017 at 12:31 PM
Font : A-A+

Diagnose Asthma more Accurately with a New Test

Asthma affects about 24 million Americans every year. But, there is no accurate method or procedure to diagnose the disease. Common symptoms, such as shortness of breath, wheezing, and cough, are relatively non-specific, and physicians may use multiple tests and observations to reach an accurate diagnosis.

In order to assess the accuracy and reliability of one of these tests that can be added to the clinician's toolbox to diagnose asthma that is fractional exhaled nitric oxide (FeNO) concentration. A research team gathered and analyzed data from previous peer-reviewed studies. They conclude that the FeNO test has moderate accuracy for patients aged 5 and older. Their results are reported in Mayo Clinic Proceedings

Advertisement


Researchers from the AHRQ-funded Evidence-based Practice Center at Mayo Clinic (Rochester, MN) identified 43 studies comprising a total of almost 14,000 adult and pediatric patients with suspected asthma who received the FeNO test. This review was commissioned by AHRQ and the National Institutes of Health, National Heart, Lung, and Blood Institute, part of the U.S. Department of Health and Human Services.

Asthma can sometimes be difficult to diagnose, and FeNO can be helpful to make therapeutic decisions more evidence based," explained lead investigator M. Hassan Murad, MD, MPH, of the Mayo Clinic. "In addition to a patient's history, the initial test is usually spirometry with an assessment of bronchodilator response. If this test does not confirm the diagnosis, but the index of suspicion for asthma is still high, measurement of FeNO may be helpful to rule in disease; although will still miss some patients with asthma."
Advertisement

Investigators evaluated FeNO data from the selected studies and categorized the results into four cutoff values, less than 20 ppb, 20 to 29 ppb, 30 to 39 ppb, and 40 ppb and over. Patients were also divided into two age groups, those older than 18 and those aged between 5 and 18.

For patients over 18, sensitivity decreased from 0.80 at <20 ppb, 0.69 at 20-29 ppb, 0.53 at 30-39 ppb to 0.41 at >40 ppb. Specificity values were 0.64, 0.78, 0.85, and 0.93, respectively. Cutoff values change the sensitivity and specificity of the FeNO test. Lower cutoffs capture more people with disease but also cause more false positive results.

According to Dr. Murad, "There is no single test that can diagnose asthma. FeNO may be a helpful tool that aids in diagnosis."

"However, patients' history, physical exam, response to treatment and other pulmonary function tests remain needed to complete the puzzle and make the diagnosis. Future research is needed to determine how FeNO can be used with other biomarkers with hopefully better accuracy that can provide a more definitive diagnosis." says Dr. Murad



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Childhood Asthma Asthma Undescended Testicles Varicocele Amyotrophic Lateral Sclerosis (ALS) Remedies for Seasonal Allergy Relief Allergy - Symptom Evaluation Wheezing Testicle Pain - Symptom Evaluation 

Recommended Reading
Asthma is a Leading Cause of Hospitalization in Preschoolers
Asthma symptoms affect an estimated 26 million Americans, and it affects almost 1 in 10 children in ...
Trees May Reduce Asthma Attacks
Asthma attacks have been found to be reduced in tree-lined urban neighborhoods. Respiratory health ....
Six Preventive Measures that Help Reduce Exposure to Allergens
Allergens are widely spreading in U.S. homes, but are highly variable. The presence of pets and ......
Digital Self-Guided Breathing Intervention for Asthma
A digital self-guided breathing retraining intervention that offers breathing exercises for asthma ....
Allergy - Symptom Evaluation
An allergic reaction may be mild or severe. It usually involves the skin, respiratory system, eyes,...
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Asthma
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways t...
Childhood Asthma
Childhood asthma is a condition that affects airways in children and interferes with their daily act...
Remedies for Seasonal Allergy Relief
Understanding the cause and mechanism of seasonal allergy can help in choosing the right treatment. ...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...
Wheezing
Wheezing is a sound arising from the airways due to an obstruction or narrowing, which prevents the ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use