About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Depression Leads to Increased Inflammatory Protein Linked to Heart Disease

by Tanya Thomas on October 9, 2009 at 8:29 AM
Font : A-A+

 Depression  Leads  to Increased Inflammatory Protein  Linked  to Heart Disease

Researchers at Indiana University-Purdue University Indianapolis opine that depression leads to elevated inflammatory proteins in the human body.

Led by Dr. Jesse Stewart, researchers found that depressive symptoms are associated with increases over time in interleukin-6, an inflammatory protein that predicts cardiovascular events.

Advertisement

On the other hand, levels of interleukin-6 were not linked to subsequent increases in depressive symptoms.

The new study is the first to examine both directions of the depression-inflammation connection and to measure the physical symptoms of depression, such as fatigue and sleep disturbance, in addition to the cognitive-emotional symptoms, such as pessimism and sadness.
Advertisement

While many previous studies have linked depression to increased inflammatory protein levels measured at the same time, but they couldn't speak to which is the cause and which is the effect.

"There is two-way communication between the brain and the immune system, so we had to determine whether activation of the body's immune system sent a signal to the brain to affect mood and behavior or whether the depression activated the immune system," said Dr. Stewart.

The participants in the study consisted of 263 healthy men and women aged 50-70 years at the start of the study.

They were tested at baseline and again six years later to determine their levels of depressive symptoms and interleukin-6.

Levels of C-reactive protein, another inflammatory protein, were also measured but were not related to depression.

Stewart said that the strength of the association of depression with future heart disease is similar to that of traditional risk factors like smoking, high blood pressure and elevated cholesterol.

"Promotion of inflammation may be one pathway through which depression may 'get under the skin' to negatively influence cardiovascular health. The link to cardiovascular disease demonstrates that there may be physical as well as mental health reasons to treat depression," said Stewart.

The study has been published in the latest issue of the journal Brain, Behavior and Immunity.

Source: ANI
TAN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Top 10 Foods for Decreasing DHT Production and Preventing Hair Fall
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Adolescence Depression Depression Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Stress Relief Through Alternative Medicine Silent Killer Diseases Andropause / Male Menopause Heart 

Most Popular on Medindia

Color Blindness Calculator Indian Medical Journals Selfie Addiction Calculator Post-Nasal Drip Pregnancy Confirmation Calculator Loram (2 mg) (Lorazepam) Nutam (400mg) (Piracetam) A-Z Drug Brands in India Vent Forte (Theophylline) Noscaphene (Noscapine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Depression Leads to Increased Inflammatory Protein Linked to Heart Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests