About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Curcumin can Help Combat Parkinson's Treatment

by Sheela Philomena on March 21, 2012 at 1:31 PM
Font : A-A+

 Curcumin can Help Combat Parkinson's Treatment

Curcumin a compound found in turmeric can help prevent clumping of a protein involved in Parkinson's disease.

A team of researchers led by Basir Ahmad, a Michigan State University postdoctoral researcher, demonstrated earlier this year that slow-wriggling alpha-synuclein proteins are the cause of clumping, or aggregation, which is the first step of diseases such as Parkinson's.

Advertisement

Now, a new study led by Ahmad has found that curcumin can help prevent clumping.

"Our research shows that curcumin can rescue proteins from aggregation, the first steps of many debilitating diseases," said Lisa Lapidus, MSU associate professor of physics and astronomy who co-authored study with Ahmad.
Advertisement

"More specifically, curcumin binds strongly to alpha-synuclein and prevents aggregation at body temperatures," she stated.

Lapidus' lab uses lasers to study protein folding. Proteins are chains of amino acids that do most of the work in cells. Scientists understand protein structure, but they don't know how they are built - a process known as folding.

Lapidus' team is shedding light on the process by correlating the speed at which protein folds with its tendency to clump or bind with other proteins.

When curcumin attaches to alpha-synuclein it not only stops clumping, but it also raises the protein's folding or reconfiguration rate. By bumping up the speed, curcumin moves the protein out of a dangerous speed zone allowing it to avoid clumping with other proteins.

Finding a compound that can fix a protein when it first begins to misfold can lead scientists to identify drugs that can treat certain diseases. Doctors won't be prescribing curcumin pills any time soon, though, Lapidus said.

"Curcumin's usefulness as an actual drug may be pretty limited since it doesn't go into the brain easily where this misfolding is taking place," she said.

"But this kind of study showcases the technique of measuring reconfiguration and opens the door for developing drug treatments," she noted.

Results of the study appeared in the current issue of the Journal of Biological Chemistry.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Turmeric Nutritional Management of Parkinsons disease Why You Should Start Drinking Turmeric (Golden) Milk Right Away Top 6 Benefits of Turmeric Extract for Diabetics 

Most Popular on Medindia

Sanatogen Pregnancy Confirmation Calculator Color Blindness Calculator Find a Hospital Loram (2 mg) (Lorazepam) Daily Calorie Requirements Hearing Loss Calculator Iron Intake Calculator Blood - Sugar Chart Blood Pressure Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Curcumin can Help Combat Parkinson's Treatment Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests