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Cough and Sputum in Long COVID Linked to Initial Infection

by Colleen Fleiss on Nov 18 2023 8:16 PM
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Cough and Sputum in Long COVID Linked to Initial Infection
Individuals who had acute COVID-19 are prone to prolonged cough and increased sputum production as part of long COVID (1 Trusted Source
Cough and sputum in long COVID are associated with severe acute COVID-19

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The study, published in the journal Respiratory Research, aimed to identify specific risk factors for cough and sputum //in patients with long COVID.

COVID-19 Hospitalized Patients: Long-term Cough Analysis

Researchers from Keio University in Tokyo enrolled hospitalized patients with COVID-19 aged 18 years from 26 medical institutions.At the three, six, and 12-month follow-ups, there were no differences in the incidence rates of wet and dry coughs. But the proportion of patients producing sputum without coughing rose over time compared with those with both sputum production and coughing.At all follow-up visits, analyses of cough and sputum production identified the risk factors for persistent symptoms as the use of intermittent mandatory ventilation (IMV), smoking, and older age.

At 12 months, severe COVID-19 was associated with cough and sputum production based on imaging findings, kidney and liver abnormalities, pulmonary blood clots, and higher levels of lactate dehydrogenase (indicating organ or tissue damage), Krebs von den Lungen-6 (indicating lung inflammation or damage), and hemoglobin A1c (indicating elevated blood glucose).

“These findings emphasize that a preventive approach including appropriate vaccination and contact precaution and further development of therapeutic drugs for COVID-19 are highly recommended for patients with risk factors for severe infection to avoid persistent respiratory symptoms,” the researchers said.

Further investigations are needed to elucidate the underlying mechanisms and develop specific therapeutic drugs for these persistent symptoms in patients with long COVID, the researchers said.

Reference:
  1. Cough and sputum in long COVID are associated with severe acute COVID-19 - (https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-023-02591-3)

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