Weight loss can be achieved in patients with non-alcoholic fatty liver disease (NAFLD) with the help of a web-based lifestyle modification intervention, reveals a new study. The results of this Italian study, which were presented at The International Liver Congress™ 2018 in Paris, France, also suggested that the degree of weight loss achieved by some patients in both intervention groups was likely to have resulted in fibrosis regression. 'We were impressed that more than one in 10 patients in both intervention groups achieved a weight loss target of 10%', said Professor Giulio Marchesini from the University of Bologna, Italy, who presented the study findings. 'This weight loss threshold has been associated with resolution of non-alcoholic steatohepatitis and regression of fibrosis in studies that have evaluated NAFLD histology'. ‘A web-based lifestyle modification intervention is much feasible in achieving weight loss in non-alcoholic fatty liver disease (NAFLD) patients.’ NAFLD is the most common liver disease in Western countries and is characterized by excessive hepatic fat accumulation. The global prevalence of NAFLD has been estimated to have reached 25% of adults,3 and both genetic and lifestyle factors contribute to the pathogenesis of the disease. Lifestyle modifications geared towards weight loss, increased physical activity and improved dietary habits are central to the management of NAFLD, and structured intervention program are recommended in the guidelines. 'Lifestyle changes are mandatory for patients with NAFLD, but these are very difficult to achieve in busy clinical units', explained Prof. Marchesini. 'We wanted to develop a web-based program to help them achieve these changes, and to compare its effects with a structured, face-to-face program involving a multidisciplinary team. The participation of patients with NAFLD in structured lifestyle program may be jeopardized by job and other time constraints, and a web-based intervention may be better suited to young, busy patients'. The study undertaken by Prof. Marchesini and colleagues included 716 patients with NAFLD. They either attended a 5-week intensive group-based lifestyle modification program, created by a multidisciplinary team of physicians, dietitians and psychologists which encouraged a healthy diet and regular physical activity (n=438), or participated in a web-based intervention (n=278). The web-based program included five modules, with interactive games, offline contact with the study center, and questionnaires. Surrogate markers of NAFLD severity were tested at 6-, 12-, and 24-months of follow-up. The primary outcome measure for the study was the percentage of patients who achieved 10% weight loss. According to Prof. Marchesini, body mass index decreased in both groups by almost 2 points, and the 10% weight loss target was achieved by 14% of all participants (12% of participants in the web-based intervention and 15% in the group-based intervention). All liver enzymes decreased significantly, irrespective of the intervention, but individuals in the web-based intervention were more likely than those in the group intervention to have a normal alanine aminotransferase (ALT) level at both 6 months (OR 2.34; 95% CI 1.27, 4.30) and 12 months (OR 2.22; 95% CI 1.33, 3.73). Surrogate markers of fibrosis decreased in both intervention groups, with statistically significant improvements from baseline observed in the Fibrosis-4 (FIB-4) index. 'Our study has shown that a web-based lifestyle modification program is a feasible and practical way of achieving a clinically meaningful level of weight loss in our NAFLD patients', said Prof. Marchesini. 'Ideally, we would now like to roll out the intervention to other liver units'. 'Weight loss has long been recognized as an effective therapy for NAFLD, but the challenge has been creating the infrastructure to achieve it', said Prof. Phil Newsome from the Queen Elizabeth Hospital and University of Birmingham, Birmingham, UK, and EASL Governing Board Member. 'Most studies have used conventional resource-intensive regimens which are not widely available in most clinical practices. This study by Prof. Marchesini demonstrates the potential of web-based approaches to achieve this at scale. The challenge now will be to see if patients are able to sustain the weight loss for longer periods of time'.Source: Eurekalert << Just by Imagining an Object Our Perception of Sound can Cha... Fecal Microbiota Transplantation Enhances Cognitive and Clin... >> Recommended Reading High Consumption of Red Meat may Cause Non-alcoholic Fatty Liver Disease (NAFLD) NAFLD (non-alcoholic fatty liver disease) and insulin resistance may be caused due to high consumption of red and processed meat. READ MORE Non-invasive Tool to Screen Non-alcoholic Fatty Liver Disease Framingham Steatosis Index considers factors like age, gender, hypertension, triglyceride levels, diabetes, the ratio of liver enzymes to diagnose NAFLD. READ MORE Indian Scientists Closer to Treating Non-Alcoholic Fatty Liver Disease A new mechanism through which the liver hoards up extra fat from sources other than alcohol has been discovered by Indian researchers. READ MORE Regular Exercise Reduces Liver Fat, Improves Non-Alcoholic Fatty Liver Disease A short, moderate and daily exercise regimen, regardless of volume or intensity, benefits obese and overweight adults who have non-alcoholic fatty liver disease. READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Blood Pressure Calculator Sanatogen Post-Nasal Drip More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?