Non-alcoholic fatty liver disease (NAFLD) is the most common liver affliction across the globe. It affects more than 30% adult Indians and occurs when more than 5 to 10% of the liver's weight is fat. There is no definite therapy for the disease. Advancing the hunt for elusive therapeutics against NAFLD, the Indian researchers have discovered a new mechanism through which the liver hoards up extra fat from sources other than alcohol. They have also identified a brand new drug target for potential therapy for the disease, that tends to develop in people who are overweight or obese or have type-2 diabetes. ‘A new mechanism through which the liver hoards up extra fat from sources other than alcohol has been discovered by Indian researchers.’ Moreover, a significant number of NAFLD patients progress to the most extreme form of the disease called non-alcoholic steatohepatitis (NASH), an irreversible clinical condition that causes the liver to swell and become damaged and trigger cirrhosis in adults. The senior researcher Partha Chakrabarti's research group along with Saikat Chakrabarti's laboratory at Indian Institute of Chemical Biology, a unit of CSIR, decided to take a shot at the silent, crippling disease that evolves over decades, its prevalence advantaged with low public awareness. They literally copped their eyes on to the cell's protein degradation machinery to zero-in on the target protein COP1. "Multiple molecular mechanisms believed to cause NAFLD have been put forward over the years. However, we identified a hitherto unknown mechanism for the control of liver fat," Chakrabarti, Cell Biology & Physiology Division at the institute told IANS. "We find that inhibition of COP1 can significantly reduce liver fat in NAFLD. However, it is still not clear whether COP1 can halt disease progression or can prevent NASH. We are currently working in this direction," Chakrabarti added. The study has been published in the journal Diabetes, from American Diabetes Association (ADA). According to CSIR-IICB Director Samit Chattopadhyay, the development will motivate the scientific community to come up with new solutions to this global problem and is "geared towards India's goal of delivering translational research outputs to the nation."Source: IANS << Get This Year's Flu Shot Via Injection: Centers for Disease... Think Again Before Going for Skin Lightening, Whitening Sol... >> Recommended Reading Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Non-invasive Tool to Screen Non-alcoholic Fatty Liver Disease Framingham Steatosis Index considers factors like age, gender, hypertension, triglyceride levels, diabetes, the ratio of liver enzymes to diagnose NAFLD. READ MORE Regulatory Proteins HNF6, Rev-erb-alpha Crucial in Fatty Liver Disease Deleting the protein HNF6 which activates protein transcription, in liver cells of adult transgenic mice leads to fatty liver syndrome. READ MORE Higher Mortality Rate in Lean Patients With Fatty Liver Disease Lean patients with nonalcoholic fatty liver disease have higher overall mortality rate than obese persons, despite being of a healthier weight, reports a new research. READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sinopril (2mg) (Lacidipine) Drug Side Effects Calculator Vent Forte (Theophylline) More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?