About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Indian Scientists Closer to Treating Non-Alcoholic Fatty Liver Disease

by Dr. Trupti Shirole on October 3, 2016 at 2:47 PM
Font : A-A+

 Indian Scientists Closer to Treating Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is the most common liver affliction across the globe. It affects more than 30% adult Indians and occurs when more than 5 to 10% of the liver's weight is fat. There is no definite therapy for the disease.

Advancing the hunt for elusive therapeutics against NAFLD, the Indian researchers have discovered a new mechanism through which the liver hoards up extra fat from sources other than alcohol.

Advertisement


They have also identified a brand new drug target for potential therapy for the disease, that tends to develop in people who are overweight or obese or have type-2 diabetes.

Moreover, a significant number of NAFLD patients progress to the most extreme form of the disease called non-alcoholic steatohepatitis (NASH), an irreversible clinical condition that causes the liver to swell and become damaged and trigger cirrhosis in adults.
Advertisement

The senior researcher Partha Chakrabarti's research group along with Saikat Chakrabarti's laboratory at Indian Institute of Chemical Biology, a unit of CSIR, decided to take a shot at the silent, crippling disease that evolves over decades, its prevalence advantaged with low public awareness.

They literally copped their eyes on to the cell's protein degradation machinery to zero-in on the target protein COP1.

"Multiple molecular mechanisms believed to cause NAFLD have been put forward over the years. However, we identified a hitherto unknown mechanism for the control of liver fat," Chakrabarti, Cell Biology & Physiology Division at the institute told IANS.

"We find that inhibition of COP1 can significantly reduce liver fat in NAFLD. However, it is still not clear whether COP1 can halt disease progression or can prevent NASH. We are currently working in this direction," Chakrabarti added.

The study has been published in the journal Diabetes, from American Diabetes Association (ADA).

According to CSIR-IICB Director Samit Chattopadhyay, the development will motivate the scientific community to come up with new solutions to this global problem and is "geared towards India's goal of delivering translational research outputs to the nation."

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Liver Biopsy Hepatitis A Liver Wilson's Disease Biliary Cirrhosis Milk Thistle Current Treatments for Liver Cancer Fatty Liver Disease: A Growing Health Problem in India Living Donor Liver Transplant: What Are the Risks? 

Most Popular on Medindia

Blood Pressure Calculator Find a Hospital Blood Donation - Recipients Find a Doctor Color Blindness Calculator A-Z Drug Brands in India Indian Medical Journals Accident and Trauma Care Calculate Ideal Weight for Infants Sanatogen
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Indian Scientists Closer to Treating Non-Alcoholic Fatty Liver Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests