About Careers MedBlog Contact us

British Researchers Develop New Technique to Spot Resistant Tuberculosis Faster

by Bidita Debnath on May 14, 2015 at 12:26 AM
Font : A-A+

British Researchers Develop New Technique to Spot Resistant Tuberculosis Faster

A new technique is being developed by a team of British researchers that reduces the time from weeks to days in genetically sequencing the bacteria causing tuberculosis.

"This could help health service providers to better treat disease, control transmission of this infection and monitor outbreaks," said scientists from University College London.


"Using the conventional methods, patients with resistant TB would need to wait for up to six weeks for antibiotic resistance testing," said senior author professor Judith Breuer from University College London.

"Our technique and the associated software could reduce testing for antimicrobial resistance to a few days, allowing doctors to give precise antimicrobial treatment earlier than is currently possible," Breuer noted.

The whole genome sequencing reveals the complete genetic (DNA) sequence of an Mtb sample, in many cases pinpointing drug resistance mutations so that appropriate treatments can be given.

The new method allows scientists to enrich Mtb DNA directly from patient sputum (mucus) samples. The samples can be sequenced and analyzed straight away, avoiding the need to spend weeks growing them in the lab.

To extract Mtb from sputum samples, the researchers used probes made of ribonucleic acid (RNA) molecules, engineered to bind to Mtb DNA. The sequencing results from sputum matched perfectly with those from the relevant cultured isolates.

"As well as delivering personalized treatments to patients, the tests could also be used to precisely track the spread of TB," explained co-lead author Josephine Bryant from UCL Infection & Immunity).

The study was published in the Journal of Clinical Microbiology.

Source: IANS


Recommended Reading

Latest General Health News

More Than 300 People on Texas-Mexico Cruise Ship Fall Sick
Over 300 people had fallen sick with illness caused by Norovirus on a US cruise ship, say authorities.
 No Smoking Day 2023: Ex-smokers in Wakefield Lead the Campaign
Ex-smokers in Wakefield have shared their stories to encourage others to give up cigarettes on No Smoking Day 2023 which falls on 8th March.
New Protein Linked to Neurodegeneration
Total levels of m6A in the nervous system rise with age and that (some) neurodegenerative diseases are characterized by RNA hypermethylation.
How Stress Disrupts Maturation of Brain's Reward Circuits?
New study provides insights into the impact of early-life adversity on brain development and on control of reward behaviors that underlie emotional disorders
 Indonesia Partners With FIND for Diagnostic Testing Access Initiative
Ministry of Health of the Republic of Indonesia signed a formal memorandum of understanding (MOU) that will expand access to essential diagnostics in the country.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

British Researchers Develop New Technique to Spot Resistant Tuberculosis Faster Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests