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Blood-brain Barrier Proteins When Blocked may Improve Effectiveness of Brain Disorder Drugs

by Kalyani Thivakaran on December 2, 2014 at 2:07 PM
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 Blood-brain Barrier Proteins When Blocked may Improve Effectiveness of Brain Disorder Drugs

Scientists have found that proteins at the blood-brain barrier tend to pump out riluzole, the only FDA-approved drug for Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, limiting the drug's effectiveness, through research in mice. However, when the investigators blocked these proteins, the effectiveness of riluzole increased and the animals experienced improved muscle function, slower disease progression and prolonged survival.

The findings suggest that blocking these transporter proteins at the blood-brain barrier might improve delivery and ultimately, efficacy of drugs used to treat ALS and other brain disorders.


"This is a proof-of-principle study that sheds light into a basic pathological mechanism at play in ALS that negatively affects our ability to deliver drugs efficiently," said Dr. Piera Pasinelli, senior author of the Annals of Clinical and Translational Neurology study. "If the findings hold true in clinical trials, we'll have the opportunity not only to improve the efficacy of an already approved ALS drug, but also to design better therapeutic strategies moving forward."

Source: Eurekalert


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