About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Bladder Microbiome may Impact Incidence and Severity of Urologic Diseases

by Anjali Aryamvally on April 7, 2018 at 1:18 PM
Font : A-A+

Bladder Microbiome may Impact Incidence and Severity of Urologic Diseases

The human bladder hosts a significant microbiome, revealed more sensitive cultivation methods and precise 16S rRNA gene sequencing techniques. The diverse bacteria inside the bladder also impact pediatric urologic diseases.

As recently as one decade ago, the human bladder was thought to be a sterile landscape. In recent years that view has shifted radically, opening brand-new fields of research aimed at clarifying the role the microbiome plays in common urologic diseases that affect children, according to a review article published by Current Urology Reports.

Advertisement


"There is a growing appreciation for the role of diverse bacteria in contributing to improved health as well as triggering disease processes or exacerbating illness," says Michael H. Hsieh, M.D., Ph.D., director of the Clinic for Adolescent and Adult Pediatric Onset Urology (CAPITUL) at Children's National Health System and study senior author. "Already, we know that probiotics and dietary modifications have the potential to play powerful roles in preventing urinary diseases that commonly occur among pediatric patients," Dr. Hsieh says. This underscores the importance of conducting even more studies to improve our understanding and to identify new therapies for health conditions that resist current treatment options."

The review conducted by Dr. Hsieh and co-authors highlights the effects of the microbiome on a number of urologic diseases that affect children, including:
Advertisement

Urinary tract infection: A number of studies point to the association between decreased microbial diversity and the incidence of what is commonly called urinary tract infection (UTI) or "dysbiosis." This relationship suggests that using probiotics to replace or supplement antibiotics could favorably alter the urinary microbiome. Future research will focus on the pathophysiological role of the microbiome to determine whether it can be manipulated to prevent or treat UTIs.

• Urge urinary incontinence: While data vary by study, the presence of bacteria in the urine, especially certain bacterial species--such as Gardnerella, Staphylococcus, Streptococcus, Actinomyces, Aerococcus, Corynebacterium and Oligella--are linked to the incidence and severity of urge urinary incontinence (UUI) as well as treatment success. Most studies find an association between greater genitourinary biodiversity and reduced incidence and lessened severity of UUI as well as improved treatment response. Future research will focus on further clarifying this relationship.

• Urolithiasis Calcium oxalate stones, the most common type of kidney stone, have a microbiome that differs from the urinary microbiome leading researchers to question whether the stone's own bacterial makeup could help to predict recurrence of future kidney stones. What's more, Oxalobacter formigenes, a gram-negative bacterium, lowers oxalate levels in the blood and are associated with a 70 percent reduction in the risk of kidney stones forming. In an experimental model, fecal transplants with the full microbiome represented had a pronounced and persistent effect on oxalate production. Patients who receive some antibiotics often have reduced rates of O. formigenes colonization. However, the bacteria are resistant to amoxicillin, augmentin, ceftriaxone and vancomycin, which could point to preferential use of these antibiotics to stave off disease and ward off kidney stone formation.



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Research News

 New Insights into How the Immune System Responds to Spinal-Cord Injuries
New study findings delineate how aging affects the immune response following Spinal cord injury (SCI) and highlight the participation of the spinal cord meninges in repair.
Nearsightedness: Atropine Eye Drops may Slow Progression in Kids
A recent clinical trial suggests that the first medication therapy to reduce the progression of nearsightedness in children could be on the way.
Autoimmune Diseases Affect One in Ten: Study
Autoimmune disorders were found to be linked to Sjogren's, systemic lupus erythematosus, and systemic sclerosis.
Remarkable Journey of Transforming Lives With Brain Pacemaker
Successful brain pacemaker implantation has helped a 51year old Parkinson's disease patient to revitalize her quality of life.
What Are the Effects of Healthy Lifestyle on Osteoarthritis?
Recent recommendations on lifestyle behaviors to prevent progression of rheumatic and musculoskeletal diseases revealed.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Bladder Microbiome may Impact Incidence and Severity of Urologic Diseases Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests