Treatment of non-ST-segment elevation myocardial infarction (NSTEMI) with anticoagulant fondaparinux, as compared to low-molecular-weight heparin (LMWH), had a lower risk of major bleeding events and death both in the hospital and after six months.
Researchers analyzed data from a Swedish registry that included 40,616 patients with NSTEMI who received in-hospital treatment with fondaparinux or LMWH between September 2006 through June 2010, with follow-up through December 2010. 14,791 patients (36.4 percent) received fondaparinux and 25,825 (63.6 percent) received LMWH.
It was seen that the absolute rate of severe in-hospital bleeding events was lower in the fondaparinux group than the LMWH group (1.1 percent vs 1.8 percent), as was in-hospital mortality (2.7 percent vs 4.0 percent). The differences in major bleeding events and mortality between the two treatments were similar at 30 days and 180 days. The rate of recurrent heart attack was 9.0 percent in the fondaparinux group, and 9.5 percent in the LMWH group at 30 days and was 14.2 percent and 15.8 percent respectively at 180 days. The rate of stroke was low in both the groups. The rate of recurrent heart attack in the fondaparinux group was 9.0 percent vs 9.5 percent in the LMWH group at 30 days and was 14.2 percent vs 15.8 percent at 180 days. The rate of stroke was low in both groups. The results were consistent in patients with varying degrees of kidney function and in the subgroup of patients with NSTEMI who had undergone early percutaneous coronary intervention (a procedure used to open narrowed coronary arteries, such as stent placement).
The study is published in 'JAMA'.