Wilson, 38, was transported to St John's hospital in Santa Monica, California on Sunday. Gossip magazines said that he had cut his left wrist and taken an indeterminate amount of pills.
"I respectfully ask that the media allow me to receive care and heal in private during this difficult time," Wilson said in a statement.
Wilson was reportedly discovered by a family member, who summoned help. He is said to have arrived at the hospital in a very serious condition. His wrist was sutured and bandaged before he was transferred to Cedar-Sinai Hospital, where he underwent a detoxification procedure, reports said Monday.
Wilson, 38, has starred in a number of successful films, including "The Royal Tenenbaums", for which he earned a writing Academy Award nomination, and "Zoolander".
Regarded as a fun-loving bachelor, Wilson is nicknamed the Butterscotch Stallion and was last involved with actress Kate Hudson. The relationship ended in June and according to celebrity reports it plunged Wilson into depression.