About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Meningococcal Vaccine can Now Protect Against 91% of Bacterial Strains

by Rishika Gupta on November 24, 2017 at 2:30 PM
Font : A-A+

Meningococcal Vaccine can Now Protect Against 91% of Bacterial Strains

Serogroup B meningococcal disease caused by Neisseria meningitidis in children and young adults can now be covered by a four-component vaccine called MenB-4C (Bexsero), found a new study published in mSphere,an open access journal from the American Society for Microbiology.

Researchers used a laboratory test called the Meningococcal Antigen Typing System (MATS) to study the coverage potential of the MenB-4C vaccine, which was approved by the Food and Drug Administration in January 2015 for use in individuals ages 10-25 years.

Advertisement


The vaccine contains 4 antigens to prevent invasive meningococcal disease caused by the serogroup B form of the bacteria Neisseria meningitidis: factor H binding protein (fHBP), Neisserial heparin binding protein (NHBA), Neisserial adhesin A (NadA) and PorA-containing outer membrane vesicles.

These antigens are found on the bacteria, and vaccination with them induces an immune response in the recipients that helps protect them from infection by the bacteria that carry the antigens.
Advertisement

In the United States in 2015, serogroup B strains of the bacteria caused approximately 40 percent of invasive meningococcal disease in all age groups, including adolescents, and over 60 percent of cases in infants aged less than one year.

Researchers tested 442 N. meningitidis serogroup B samples collected by CDC from 2000 to 2008. The MATS test predicted that 91 percent of these bacterial strains causing meningococcal disease in the United States would be covered by the MenB-4C vaccine, with an estimated coverage ranging from 88 percent to 97 percent each year.

More than half of the covered strains could be targeted by two or more antigens in the vaccine, the investigators found. NHBA covered 83 percent of the strains, fHBP covered 53 percent of the strains, PorA covered 5.9 percent of the strains and NadA covered 2.5 percent of the strains.

"We are very pleased to see that it looks like the vaccine has the potential to cover most of the strains of meningococcal Group B bacteria currently circulating in the U.S.," said lead study author Gowrisankar Rajam, Ph.D., health scientist at CDC.

"However, we need to continue our analysis to assess the coverage of currently circulating strains in the U.S. We are confident the MATS technique will be very useful at detecting any changes in bacterial expression of these antigens."

Neisseria meningitidis is a leading cause of bacterial meningitis in children and young adults, resulting in significant morbidity and mortality worldwide. Meningococcal disease is a life-threatening illness that can infect the bloodstream and the lining that surrounds the brain and spinal cord.

The bacteria can be transmitted from person to person through close or prolonged contact with respiratory or throat secretions, such as by coughing, kissing or living in close quarters.

Another vaccine against serogroup B meningococcal disease, called Trumenba, was approved by the FDA in October 2014. Previous vaccines were available to protect against meningococcal disease caused by N. meningitidis serogroups A, C, Y and W but not against serogroup B.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Vaccination for Children Top 10 Vaccine Myths Debunked 

Recommended Reading
Meningococcal Vaccine Does Not Hamper Efficacy of Other Routine Infant Vaccines
A study in the February 8 issue of JAMA says that administration of routine infant immunizati...
Scientists Make New Discovery in Fight Against Deadly Meningococcal Disease
Professor Jennings said, "Neisseria meningitidis is an important human pathogen that can cause ......
Targeting University Freshers Could Help Reduce the Spread of Meningitis
A campus-based vaccination campaign was successful in ensuring that almost three-quarters of ......
Britain's NHS Launches World's First Meningitis B Vaccination Program
The vaccine could potentially prevent over 4,000 cases of meningococcal disease in children under .....
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...
Vaccination for Children
Vaccines are biological products that impart immunity to the recipient. Vaccines may be live attenua...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use