Nat Commun
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice.
Keipert S, Lutter D, Schroeder BO, Brandt D, Ståhlman M, Schwarzmayr T, Graf E, Fuchs H, de Angelis MH, Tschöp MH, Rozman J, Jastroch M
Uncoupling protein 1 (UCP1) executes thermogenesis in brown adipose tissue, which is a major focus of human obesity research. Although the UCP1-knocko ...
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Source: PubMed
Mol. Cell. Endocrinol. 2020 Jan 28
Associations of maternal diet and placenta leptin methylation.
Daniels TE, Sadovnikoff A, Ridout KK, Lesseur C, Marsit CJ, Tyrka AR
Maternal diet is an important factor in prenatal development that also has implications for disease risk later in life. The adipokine leptin is a key ...
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Source: PubMed
Adipocyte
Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity.
Li C, Li J, He F, Li K, Li X, Zhang Y
Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whe ...
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Source: PubMed
Adipocyte
Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4.
Li P, Fan C, Cai Y, Fang S, Zeng Y, Zhang Y, Lin X, Zhang H, Xue Y, Guan M
Nonalcoholic fatty liver disease (NAFLD), main cause of liver damage, is inextricably linked to diabetes. However, there is no specific means to impro ...
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Source: PubMed
Eur. J. Clin. Invest. 2020 Jan 30
Is Neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus? A cross sectional study.
Kocak MZ, Aktas G, Atak BM, Duman TT, Yis OM, Erkus E, Savli H
Neuregulin 4 (Nrg-4) is a new adipokine released from brown adipose tissue. It plays pivotal role in regulating systemic energy balance, glucose and l ...
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Source: PubMed
