Invest New Drugs 2020 Feb 01
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer.
Gong X, Du D, Deng Y, Zhou Y, Sun L, Yuan S
E3 ligases are a class of critical enzymes that can catalyse the transfer of ubiquitin (Ub) from an E2 enzyme to the substrate and are essential to ce ...
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Source: PubMed
J. Mol. Med. 2020 Feb 01
Altered molecular signatures during kidney development after intrauterine growth restriction of different origins.
Nüsken E, Fink G, Lechner F, Voggel J, Wohlfarth M, Sprenger L, Mehdiani N, Weber LT, Liebau MC, Brachvogel B, Dötsch J, Nüsken KD
This study was performed to identify transcriptional alterations in male intrauterine growth restricted (IUGR) rats during and at the end of nephrogen ...
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Source: PubMed
Biomed. Pharmacother.
Inhibition of MGMT-mediated autophagy suppression decreases cisplatin chemosensitivity in gastric cancer.
Lei Y, Tang L, Hu J, Wang S, Liu Y, Yang M, Zhang J, Tang B
Cisplatin (DDP) is the first-line drug for the treatment of gastric cancer (GC). However, DDP resistance is common. Autophagy, which is closely relate ...
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Source: PubMed
Biomed. Pharmacother.
Rhodiola crenulata root extract ameliorates fructose-induced hepatic steatosis in rats: Association with activating autophagy.
Yuan C, Jin Y, Yao L, Liu L, Li J, Li H, Lai Y, Chen Z, Pan Z, Han T, Ke D, Li C, Wang S, Wang M, Yamahara J, Wang J
Increasing evidence has shown the beneficial effects of Rhodiola species on metabolic disorders, but their mechanisms are not clear. Hepatic steatosis ...
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Source: PubMed
Sci. Total Environ.
6?-Feruloylspinosin alleviated beta-amyloid induced toxicity by promoting mitophagy in Caenorhabditis elegans (GMC101) and PC12 cells.
Yang T, Zhao X, Zhang Y, Xie J, Zhou A
This study aims to investigate the neuroprotective effects of 6?-feruloylspinosin (6-FS), one of the main active flavonoid components in Sour Jujube s ...
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Source: PubMed
