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Side effect(s) of Lopinavir and Ritonavir


Review the side-effects of Lopinavir and Ritonavir as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

   Most Common
- Diarrhea.

   Gastrointestinal
- Nausea, vomiting, abdominal pain, indigestion, flatulence.

   General
- Weakness.

   Metabolic
- Decreased weight and appetite.

   Musculoskeletal
- Muscle pain.

   Central Nervous System
- Headache, tingling, sleeplessness, depression, libido decreased.

   Skin
- Rash.

   Heart
- Dilatation of blood vessels.

Other Precautions :

• Oral solution should not be used in preterm neonates in the immediate postnatal period due to possible side effects.
• Patients may develop new-onset of hyperglycemia or high blood glucose.

Drug Name : Lopinavir and Ritonavir

Lopinavir and Ritonavir generic contains antiretroviral agents, prescribed for HIV-1 infection for adults and children aged above 14 days. It works by decreasing the amount of HIV in the blood by blocking a vital enzyme named protease required for viral multiplication. Update: • Ritonavir+ Lopinavir combination is claimed to treat patients with COVID-19. • New clinical trial ‘’The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection (ELACOI)’’ was started in February 2020 to know the effectiveness of the combination for treating COVID-19. • Another trial sponsored by Asan Medical Center, launched in March 2020 is comparing Lopinavir/Ritonavir with Hydroxychloroquine for treating patients with mild coronavirus disease (COVID-19). It reduces the effects of histamine in the body.


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