Lofexidine generic Lofexidine is a centrally acting α-2 adrenergic receptor agonist, prescribed for reducing the severity of opioid withdrawal symptoms in adults, with the focus to facilitate the abrupt discontinuation of opioids or following the completion of opioid therapy. Lofexidine is the first non-opioid drug approved for the symptomatic management of opioid withdrawal. Lofexidine is also used for treating women suffering from postmenopausal hot flashes .
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