How to Take Vedolizumab and it's Dose

Last Updated on May 15, 2023

• Vedolizumab should be discontinued in patients who do not show therapeutic benefit by Week 14.
• It should be reconstituted and diluted with sterile water for injection prior to the administration. It should be reconstituted and prepared by a trained healthcare professional using aseptic technique.
• Injection should be given within four hours of reconstitution and dilution.
• Visually inspect the reconstituted vedolizumab injection for any particulate matter and discoloration prior to administration. Injection should be clear or opalescent, colorless to light brownish yellow and free of visible particulates.
• Discard any remaining portion of the injection.
• Do not add other medicines to the prepared infusion solution or intravenous infusion set. Injection should be used as soon as possible after reconstitution and dilution.

Dosage & When it is to be taken

Vedolizumab is available as injection containing 300mg of drug
For adult UC and CD, it is given as 300 mg intravenous infusion over 30 minutes at zero, two and six weeks, thereafter for every eight weeks.

When it is not to be taken (Contraindications)

Vedolizumab should not be used:

• If there is an allergy to vedolizumab
• In patients with severe infections.

Drug Name : Vedolizumab

Vedolizumab injection is used for treating adult patients with moderate to severe active ulcerative colitis and Crohn’s disease who have had an inadequate response or no response or who were intolerant to other treatment methods such as with drugs that causes tumor necrosis factor (TNF) block (such as Infliximab or Etanercept) or an immunomodulatory (azathioprine, methotrexate or cyclosporine) or a corticosteroid.