Rolapitant is available in tablet and injection form which should be given 2 hours before starting chemotherapy.
Rolapitant tablets are taken orally as a single dose on day 1 with or without food.
Rolapitant injection should be given intravenously or deep into the vein slowly over 30 minutes.
Dexamethasone should be given exactly half an hour before initiating chemotherapy. On day 2, 3, and 4 dexamethasone is given twice daily.
Discard the solution if any particulate matter, discoloration or contamination is present.
This injectable solution should not be diluted. Once the vial stopper of rolapitant injection is punctured it must be used immediately.
This injection can be given with the other fluids like Sodium Chloride 0.9%, Dextrose 5% or Lactated Ringer’s solution.
Rolapitant should not be given within 2- week intervals.
Dexamethasone and other medications that control vomiting can also be added to the treatment schedule.
1. Cisplatin or highly emetogenic (emetogenic means vomiting) chemotherapy:
The recommended dose of Rolapitant is 180 mg (if taken as a tablet) or 166.5 mg if given as an injection and this should be given on day one of cancer chemotherapy.
The dose of dexamethasone is 20 mg on the first day of chemotherapy followed by 8 mg on day 2, 3, and 4 respectively.
The dose of agents to control vomiting can be given according to the drugs chosen to prescribe along with the treatment schedule.
2.Anthracycline and cyclophosphamide combination or moderately emetogenic chemotherapy:
The dosage schedule of Rolapitant is the same as prescribed for cisplatin or highly emetogenic chemotherapy but to be given only on the first day.
Medicine to control vomiting can be given on day 2, 3, and 4 of cancer chemotherapy.
No dexamethasone administrations are necessary on day 2, 3, and 4.
• Who have Allergy
• Children below 18 years of age
• Women undergoing treatment for infertility
• Severe liver damage
Rolapitant tablets are taken orally as a single dose on day 1 with or without food.
Rolapitant injection should be given intravenously or deep into the vein slowly over 30 minutes.
Dexamethasone should be given exactly half an hour before initiating chemotherapy. On day 2, 3, and 4 dexamethasone is given twice daily.
Discard the solution if any particulate matter, discoloration or contamination is present.
This injectable solution should not be diluted. Once the vial stopper of rolapitant injection is punctured it must be used immediately.
This injection can be given with the other fluids like Sodium Chloride 0.9%, Dextrose 5% or Lactated Ringer’s solution.
Dosage & When it is to be taken
The dose of rolapitant is selected based on the medication and its severity of inducing nausea and vomiting.Rolapitant should not be given within 2- week intervals.
Dexamethasone and other medications that control vomiting can also be added to the treatment schedule.
1. Cisplatin or highly emetogenic (emetogenic means vomiting) chemotherapy:
The recommended dose of Rolapitant is 180 mg (if taken as a tablet) or 166.5 mg if given as an injection and this should be given on day one of cancer chemotherapy.
The dose of dexamethasone is 20 mg on the first day of chemotherapy followed by 8 mg on day 2, 3, and 4 respectively.
The dose of agents to control vomiting can be given according to the drugs chosen to prescribe along with the treatment schedule.
2.Anthracycline and cyclophosphamide combination or moderately emetogenic chemotherapy:
The dosage schedule of Rolapitant is the same as prescribed for cisplatin or highly emetogenic chemotherapy but to be given only on the first day.
Medicine to control vomiting can be given on day 2, 3, and 4 of cancer chemotherapy.
No dexamethasone administrations are necessary on day 2, 3, and 4.
When it is not to be taken (Contraindications)
Rolapitant should not be used in patients -• Who have Allergy
• Children below 18 years of age
• Women undergoing treatment for infertility
• Severe liver damage
