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Osimertinib is available in the tablet form to be taken by mouth (orally) once a day with or without food.
In case of difficulty in swallowing, disperse the tablet in a glass of 60 mL or 2 ounces of non-carbonated water and stir until the tablet is dispersed into small pieces and swallow immediately.
Rinse the glass again with sufficient quantity of water and drink immediately as there will be some leftover tablet pieces in the container.
If the patient is on a nasogastric tube, give the tablet by dispersing it in 15 mL of non-carbonated water. Additionally, 15 mL of water may be used to transfer any residues to the syringe. The final 30 mL liquid should be administered as per the nasogastric tube instructions with water flushes not more than 30 ml.
The treatment with osimertinib can be continued until there is a disease progression. It should be continued indefinitely if the drug does not result in intolerable toxicity.
The dose of osimertinib can be reduced if any side effects occur and can be continued with the usual dose if the side effects are under control.
Permanently discontinue osimertinib therapy if the side effects are life-threatening particularly to the lungs or heart.
• If there is an allergy to the previous dose of osimertinib
• Children under 18 years of age due to the unavailability of safety and effectiveness
• Pregnant and breastfeeding mothers
• Patients undergoing treatment to correct fertility
Take the next scheduled dose of osimertinib as prescribed usually the next day.
In case of difficulty in swallowing, disperse the tablet in a glass of 60 mL or 2 ounces of non-carbonated water and stir until the tablet is dispersed into small pieces and swallow immediately.
Rinse the glass again with sufficient quantity of water and drink immediately as there will be some leftover tablet pieces in the container.
If the patient is on a nasogastric tube, give the tablet by dispersing it in 15 mL of non-carbonated water. Additionally, 15 mL of water may be used to transfer any residues to the syringe. The final 30 mL liquid should be administered as per the nasogastric tube instructions with water flushes not more than 30 ml.
Dosage & When it is to be taken
The dose of Osimertinib to be prescribed is 80 mg per day.The treatment with osimertinib can be continued until there is a disease progression. It should be continued indefinitely if the drug does not result in intolerable toxicity.
The dose of osimertinib can be reduced if any side effects occur and can be continued with the usual dose if the side effects are under control.
Permanently discontinue osimertinib therapy if the side effects are life-threatening particularly to the lungs or heart.
When it is not to be taken (Contraindications)
Osimertinib should not be used in patients:• If there is an allergy to the previous dose of osimertinib
• Children under 18 years of age due to the unavailability of safety and effectiveness
• Pregnant and breastfeeding mothers
• Patients undergoing treatment to correct fertility
What if you Miss a Dose of Osimertinib?
If a dose is missed or skipped, it is advised not to take the missed dose immediately.Take the next scheduled dose of osimertinib as prescribed usually the next day.
