• Ocrelizumab comes as a solution which has to be injected intravenously or directly into the vein.
• The injection has to be inspected for the presence of any visible particles or cloudy appearance or discoloration if any and should be discarded if present.
• The intended dose has to be withdrawn and should be diluted into an infusion bag containing 0.9% sodium chloride injection before administering. The preparation process must be handled by healthcare specialists strictly under aseptic techniques.
• Ocrelizumab injection should not be diluted with other diluents except 0.9% sodium chloride injection.
Initial dose: 300mg of infusion done intravenously followed 2 weeks later with another 300mg of intravenous infusion.
Maintenance dose: 600mg of infusion intravenously for every 6 months.
• Allergic to ocrelizumab drug
• Active infection or carrier of Hepatitis B virus
• Any case of existing infections
• Taking immunosuppressive medications
• Children below 18 years of age as the safety and efficacy of ocrelizumab injection in children has not been established
• The next dose can be reset after 6 months from the time of the missed dose. It is advised to have a time interval of at least 5 months between the two doses of infusions.
• The injection has to be inspected for the presence of any visible particles or cloudy appearance or discoloration if any and should be discarded if present.
• The intended dose has to be withdrawn and should be diluted into an infusion bag containing 0.9% sodium chloride injection before administering. The preparation process must be handled by healthcare specialists strictly under aseptic techniques.
• Ocrelizumab injection should not be diluted with other diluents except 0.9% sodium chloride injection.
Dosage & When it is to be taken
• The recommended adult dose is-Initial dose: 300mg of infusion done intravenously followed 2 weeks later with another 300mg of intravenous infusion.
Maintenance dose: 600mg of infusion intravenously for every 6 months.
When it is not to be taken (Contraindications)
Ocrelizumab should not be used in patients-• Allergic to ocrelizumab drug
• Active infection or carrier of Hepatitis B virus
• Any case of existing infections
• Taking immunosuppressive medications
• Children below 18 years of age as the safety and efficacy of ocrelizumab injection in children has not been established
What if you Miss a Dose of Ocrelizumab?
• If a scheduled dose of infusion is missed, do not wait for the next dose but take the missed dose as early as possible.• The next dose can be reset after 6 months from the time of the missed dose. It is advised to have a time interval of at least 5 months between the two doses of infusions.
