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Obinutuzumab is available in an injection form which should be given by a healthcare provider intravenously or deep into the vein slowly.
Withdraw a required quantity of obinutuzumab from the vial and dilute with 0.9% sodium chloride and mix the diluted solution by gentle inversion.
The drug should be mixed in aseptic conditions and should not be combined with other drugs.
Patients can be premedicated with certain drugs to reduce the risk of infusion-related reactions (IRR) such as nausea, fever, breathing problems, vomiting, chills, chest pain, loose stools, and dizziness.
The drugs used for premedication include-
• Intravenous steroid (Dexamethasone 20 mg or Methylprednisolone 80 mg)
• Paracetamol or acetaminophen (650 mg to 1 gm)
• Antiallergic drug (Diphenhydramine 50 mg)
Hydrocortisone should not be used as it is not much effective against reducing the effect of infusion-related reactions.
Obinutuzumab should be administered for six 28-day treatment cycles.
The loading dose of obinutuzumab for the first cycle includes 100 mg on day 1 which can be increased to 900 mg on day 2 followed by 1000 mg of obinutuzumab on days 8 and 15.
The dose of obinutuzumab from cycles 2 to 6 is 1000 mg given on day 1.
Follicular lymphoma:
The dose of obinutuzumab should be given for 6 to 8 treatment cycles (28-day) followed by obinutuzumab monotherapy for every two months given for up to two years.
During cycle 1, the loading dose of obinutuzumab is 1000 mg given on days 1, 8, and 15. From cycles 2 to 8, the dose of obinutuzumab is 1000 mg given on day 1.
The maintenance dose is given with obinutuzumab alone after two months of the last dose of the 8th cycle followed by every two months for up to 2 years.
• If there is an allergy to obinutuzumab
• Pregnancy and breastfeeding
• Children below 18 years of age
• Immunization with live viral vaccines (e.g., MMR, Polio, Typhoid)
• History of serum sickness or active infection
The next dosing schedule of obinutuzumab can be adjusted to maintain an adequate time interval between the two doses.
Withdraw a required quantity of obinutuzumab from the vial and dilute with 0.9% sodium chloride and mix the diluted solution by gentle inversion.
The drug should be mixed in aseptic conditions and should not be combined with other drugs.
Patients can be premedicated with certain drugs to reduce the risk of infusion-related reactions (IRR) such as nausea, fever, breathing problems, vomiting, chills, chest pain, loose stools, and dizziness.
The drugs used for premedication include-
• Intravenous steroid (Dexamethasone 20 mg or Methylprednisolone 80 mg)
• Paracetamol or acetaminophen (650 mg to 1 gm)
• Antiallergic drug (Diphenhydramine 50 mg)
Hydrocortisone should not be used as it is not much effective against reducing the effect of infusion-related reactions.
Dosage & When it is to be taken
Chronic lymphocytic leukemia: (CLL)Obinutuzumab should be administered for six 28-day treatment cycles.
The loading dose of obinutuzumab for the first cycle includes 100 mg on day 1 which can be increased to 900 mg on day 2 followed by 1000 mg of obinutuzumab on days 8 and 15.
The dose of obinutuzumab from cycles 2 to 6 is 1000 mg given on day 1.
Follicular lymphoma:
The dose of obinutuzumab should be given for 6 to 8 treatment cycles (28-day) followed by obinutuzumab monotherapy for every two months given for up to two years.
During cycle 1, the loading dose of obinutuzumab is 1000 mg given on days 1, 8, and 15. From cycles 2 to 8, the dose of obinutuzumab is 1000 mg given on day 1.
The maintenance dose is given with obinutuzumab alone after two months of the last dose of the 8th cycle followed by every two months for up to 2 years.
When it is not to be taken (Contraindications)
Obinutuzumab should not be used in patients-• If there is an allergy to obinutuzumab
• Pregnancy and breastfeeding
• Children below 18 years of age
• Immunization with live viral vaccines (e.g., MMR, Polio, Typhoid)
• History of serum sickness or active infection
What if you Miss a Dose of Obinutuzumab?
If a dose of obinutuzumab is missed, give the missed dose as soon as possible.The next dosing schedule of obinutuzumab can be adjusted to maintain an adequate time interval between the two doses.
