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• Lofexidine tablets should be taken by mouth four times daily, either with or without food.
• Swallow the tablet as a whole with sufficient quantity of water.
• Patients are advised to take a part of lofexidine dose after evening meal to reduce the effect of insomnia or sleeping difficulty induced by opioid withdrawal.
• The recommended initial adult dose is three 0.18 mg tablets at a time and should not exceed four tablets (0.72 mg).
• Tablets are generally taken for the first 5 to 7 days after the last dose of opioids and can be continued over a period of 2 weeks based on the severity of withdrawal symptoms.
• The total daily dose of lofexidine should not exceed 16 tablets (2.88 mg).
• Dose adjustments are required in patients with severe kidney or liver dysfunction with one 0.18 mg tablet taken four times a day that adds to a maximum of 0.72mg per day.
• Allergy to lofexidine
• Heart disease
• History of opioid use disorder (opioid addiction)
• Severe kidney failure
• Decreased heart rhythm
• Electrolyte abnormalities (low levels of magnesium and potassium)
• Children below 12 years of age
Caution is required in treating pregnant and breastfeeding women due to lack of sufficient data; lofexidine should only be considered if the benefit outweighs the risk.
• Swallow the tablet as a whole with sufficient quantity of water.
• Patients are advised to take a part of lofexidine dose after evening meal to reduce the effect of insomnia or sleeping difficulty induced by opioid withdrawal.
Dosage & When it is to be taken
• Lofexidine tablets are available at a strength of 0.18 mg per tablet.• The recommended initial adult dose is three 0.18 mg tablets at a time and should not exceed four tablets (0.72 mg).
• Tablets are generally taken for the first 5 to 7 days after the last dose of opioids and can be continued over a period of 2 weeks based on the severity of withdrawal symptoms.
• The total daily dose of lofexidine should not exceed 16 tablets (2.88 mg).
• Dose adjustments are required in patients with severe kidney or liver dysfunction with one 0.18 mg tablet taken four times a day that adds to a maximum of 0.72mg per day.
When it is not to be taken (Contraindications)
Lofexidine should not be used in patients with-• Allergy to lofexidine
• Heart disease
• History of opioid use disorder (opioid addiction)
• Severe kidney failure
• Decreased heart rhythm
• Electrolyte abnormalities (low levels of magnesium and potassium)
• Children below 12 years of age
Caution is required in treating pregnant and breastfeeding women due to lack of sufficient data; lofexidine should only be considered if the benefit outweighs the risk.
