• Brigatinib comes as a tablet which should be taken by mouth along with food and should be taken at the same time each day.
• When the treatment with brigatinib tablets is stopped for more than 2 weeks due to adverse reactions, the treatment should be initiated with 90 mg once a day for 7 days instead of taking a higher previously tolerated dose.
• If vomiting occurs after taking brigatinib tablets or a dose is missed, do not take another dose and continue with the next scheduled dose.
• The tablets should be swallowed as a whole with sufficient quantity of water and must not be crushed or chewed.
• The tablets should be taken until disease progression or any reported toxicity.
Dose adjustment for adverse reactions:
• Temporary interruption or discontinuation of the treatment may be required in patients with side effects.
• The following dosage adjustments may be required in the presence of adverse reactions:
• If the patient is on 180 mg initially, the dosage can be reduced to 120 mg per day.
• When the adverse reactions occur at 90 mg dose the dose can be further reduced to 60 mg once daily.
• If adverse reactions occur with 60 mg dose, the brigatinib therapy should be discontinued.
• Allergy to brigatinib
• Children less than 18 years, during pregnancy and breastfeeding
• When the treatment with brigatinib tablets is stopped for more than 2 weeks due to adverse reactions, the treatment should be initiated with 90 mg once a day for 7 days instead of taking a higher previously tolerated dose.
• If vomiting occurs after taking brigatinib tablets or a dose is missed, do not take another dose and continue with the next scheduled dose.
• The tablets should be swallowed as a whole with sufficient quantity of water and must not be crushed or chewed.
Dosage & When it is to be taken
• The recommended adult dose of brigatinib is 90 mg to be taken orally once a day for first 7 days which can be increased to 180 mg orally once a day if 90 mg of brigatinib is found to be tolerated by the patient.• The tablets should be taken until disease progression or any reported toxicity.
Dose adjustment for adverse reactions:
• Temporary interruption or discontinuation of the treatment may be required in patients with side effects.
• The following dosage adjustments may be required in the presence of adverse reactions:
• If the patient is on 180 mg initially, the dosage can be reduced to 120 mg per day.
• When the adverse reactions occur at 90 mg dose the dose can be further reduced to 60 mg once daily.
• If adverse reactions occur with 60 mg dose, the brigatinib therapy should be discontinued.
When it is not to be taken (Contraindications)
Brigatinib is not recommended in patients with the following conditions:• Allergy to brigatinib
• Children less than 18 years, during pregnancy and breastfeeding
