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Regorafenib Interaction with other Drugs


Regorafenib is a kinase inhibitor, prescribed for metastatic colorectal cancer (CRC) in patients who have been previously treated with fluoropyrimidine- oxaliplatin-and irinotecan-based chemotherapy.

Regorafenib Interaction with 189 drugs. Find out more in the list below:

Acebutolol


Regorafenib may increase the bradycardic activities of Acebutolol.

Acetyl Sulfisoxazole


The metabolism of Regorafenib can be decreased when combined with Acetyl sulfisoxazole.

Acetyldigitoxin


Acetyldigitoxin may decrease the cardiotoxic activities of Regorafenib.

Afatinib


The serum concentration of Afatinib can be increased when it is combined with Regorafenib.

Alprenolol


Regorafenib may increase the bradycardic activities of Alprenolol.

Amiodarone


The metabolism of Regorafenib can be decreased when combined with Amiodarone.

Amodiaquine


The serum concentration of Amodiaquine can be increased when it is combined with Regorafenib.

Ancestim


The risk or severity of cytotoxicity can be increased when Ancestim is combined with Regorafenib.

Apalutamide


The serum concentration of Regorafenib can be decreased when it is combined with Apalutamide.

Aprepitant


The serum concentration of Regorafenib can be increased when it is combined with Aprepitant.

Asenapine


Regorafenib may increase the bradycardic activities of Asenapine.

Asunaprevir


The serum concentration of Asunaprevir can be increased when it is combined with Regorafenib.

Atazanavir


The metabolism of Regorafenib can be decreased when combined with Atazanavir.

Atenolol


Regorafenib may increase the bradycardic activities of Atenolol.

Atomoxetine


The metabolism of Regorafenib can be decreased when combined with Atomoxetine.

Atorvastatin


The risk or severity of adverse effects can be increased when Regorafenib is combined with Atorvastatin.

Betaxolol


Regorafenib may increase the bradycardic activities of Betaxolol.

Bevacizumab


Bevacizumab may increase the cardiotoxic activities of Regorafenib.

Bevacizumab-Awwb


Bevacizumab may increase the cardiotoxic activities of Regorafenib.

Bisoprolol


Regorafenib may increase the bradycardic activities of Bisoprolol.

Boceprevir


The metabolism of Regorafenib can be decreased when combined with Boceprevir.

Bopindolol


Regorafenib may increase the bradycardic activities of Bopindolol.

Bortezomib


The metabolism of Regorafenib can be decreased when combined with Bortezomib.

Bosentan


The serum concentration of Regorafenib can be decreased when it is combined with Bosentan.

Bosentan Anhydrous


The serum concentration of Regorafenib can be decreased when it is combined with Bosentan.

Bosutinib


The serum concentration of Bosutinib can be increased when it is combined with Regorafenib.

Bosutinib monohydrate


The serum concentration of Bosutinib can be increased when it is combined with Regorafenib.

Brentuximab Vedotin


The serum concentration of Brentuximab vedotin can be increased when it is combined with Regorafenib.

Bromocriptine


The risk or severity of adverse effects can be increased when Bromocriptine is combined with Regorafenib.

Bupranolol


Regorafenib may increase the bradycardic activities of Bupranolol.

Cabazitaxel


The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Regorafenib.

Cabergoline


The risk or severity of adverse effects can be increased when Cabergoline is combined with Regorafenib.

Carbamazepine


The serum concentration of Regorafenib can be decreased when it is combined with Carbamazepine.

Carteolol


Regorafenib may increase the bradycardic activities of Carteolol.

Carvedilol


Regorafenib may increase the bradycardic activities of Carvedilol.

Celiprolol


Regorafenib may increase the bradycardic activities of Celiprolol.

Ceritinib


The serum concentration of Regorafenib can be increased when it is combined with Ceritinib.

Cerivastatin


The serum concentration of Cerivastatin can be increased when it is combined with Regorafenib.

Cilostazol


The serum concentration of Cilostazol can be increased when it is combined with Regorafenib.

Clarithromycin


The serum concentration of Regorafenib can be increased when it is combined with Clarithromycin.

Clemastine


The metabolism of Regorafenib can be decreased when combined with Clemastine.

Clotrimazole


The metabolism of Regorafenib can be decreased when combined with Clotrimazole.

Cobicistat


The metabolism of Regorafenib can be decreased when combined with Cobicistat.

Colchicine


The serum concentration of Colchicine can be increased when it is combined with Regorafenib.

Conivaptan


The serum concentration of Conivaptan can be increased when it is combined with Regorafenib.

Crizotinib


The metabolism of Regorafenib can be decreased when combined with Crizotinib.

Curcumin


The metabolism of Regorafenib can be decreased when combined with Curcumin.

Cyclophosphamide


Cyclophosphamide may increase the cardiotoxic activities of Regorafenib.

Cyclophosphamide Anhydrous


Cyclophosphamide may increase the cardiotoxic activities of Regorafenib.

Cyclosporine


The metabolism of Regorafenib can be decreased when combined with Cyclosporine.

Dabigatran Etexilate


The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Regorafenib.

Dabrafenib


The serum concentration of Regorafenib can be decreased when it is combined with Dabrafenib.

Darunavir


The metabolism of Regorafenib can be decreased when combined with Darunavir.

Dasatinib


The serum concentration of Regorafenib can be increased when it is combined with Dasatinib.

Dasatinib Anhydrous


The serum concentration of Regorafenib can be increased when it is combined with Dasatinib.

Deferasirox


The serum concentration of Regorafenib can be decreased when it is combined with Deferasirox.

Delavirdine


The metabolism of Regorafenib can be decreased when combined with Delavirdine.

Desipramine


Regorafenib may increase the bradycardic activities of Desipramine.

Deslanoside


Deslanoside may decrease the cardiotoxic activities of Regorafenib.

Digitoxin


Digitoxin may decrease the cardiotoxic activities of Regorafenib.

Digoxin


Regorafenib may increase the bradycardic activities of Digoxin.

Dihydroergocornine


The risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Regorafenib.

Dihydroergocristine


The risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Regorafenib.

Dihydroergotamine


The risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Regorafenib.

Diltiazem


Regorafenib may increase the bradycardic activities of Diltiazem.

Docetaxel


The risk or severity of adverse effects can be increased when Docetaxel is combined with Regorafenib.

DOCETAXEL ANHYDROUS


The risk or severity of adverse effects can be increased when Docetaxel is combined with Regorafenib.

Doxorubicin


The serum concentration of Doxorubicin can be increased when it is combined with Regorafenib.

Doxorubicin Hydrochloride


The serum concentration of Doxorubicin can be increased when it is combined with Regorafenib.

Doxycycline


The metabolism of Regorafenib can be decreased when combined with Doxycycline.

Doxycycline Anhydrous


The metabolism of Regorafenib can be decreased when combined with Doxycycline.

Dronedarone


The metabolism of Regorafenib can be decreased when combined with Dronedarone.

Edoxaban


The serum concentration of Edoxaban can be increased when it is combined with Regorafenib.

Enzalutamide


The serum concentration of Regorafenib can be decreased when it is combined with Enzalutamide.

Ergonovine


The risk or severity of adverse effects can be increased when Ergonovine is combined with Regorafenib.

Ergotamine


The risk or severity of adverse effects can be increased when Ergotamine is combined with Regorafenib.

Erythromycin


The metabolism of Regorafenib can be decreased when combined with Erythromycin.

Esmolol


Regorafenib may increase the bradycardic activities of Esmolol.

Everolimus


The serum concentration of Everolimus can be increased when it is combined with Regorafenib.

Fluconazole


The metabolism of Regorafenib can be decreased when combined with Fluconazole.

Fluvastatin


The serum concentration of Fluvastatin can be increased when it is combined with Regorafenib.

Fluvoxamine


The metabolism of Regorafenib can be decreased when combined with Fluvoxamine.

Fosamprenavir


The metabolism of Regorafenib can be decreased when combined with Fosamprenavir.

Fosaprepitant


The serum concentration of Regorafenib can be increased when it is combined with Fosaprepitant.

Fosphenytoin


The serum concentration of Regorafenib can be decreased when it is combined with Fosphenytoin.

Fusidate


The serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid.

Fusidic Acid


The serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid.

Hypoxis hemerocallidea root extract


The serum concentration of Regorafenib can be decreased when it is combined with St. John's Wort.

Ibrutinib


The serum concentration of Ibrutinib can be increased when it is combined with Regorafenib.

Idelalisib


The metabolism of Regorafenib can be decreased when combined with Idelalisib.

Imatinib


The metabolism of Regorafenib can be decreased when combined with Imatinib.

Indinavir


The metabolism of Regorafenib can be decreased when combined with Indinavir.

INDINAVIR ANHYDROUS


The metabolism of Regorafenib can be decreased when combined with Indinavir.

Irinotecan


The serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Regorafenib.

Isavuconazole


The serum concentration of Regorafenib can be increased when it is combined with Isavuconazole.

Isavuconazonium


The metabolism of Regorafenib can be decreased when combined with Isavuconazonium.

Isradipine


The metabolism of Regorafenib can be decreased when combined with Isradipine.

Itraconazole


The serum concentration of Regorafenib can be increased when it is combined with Itraconazole.

Ivabradine


Regorafenib may increase the bradycardic activities of Ivabradine.

Ivacaftor


The serum concentration of Regorafenib can be increased when it is combined with Ivacaftor.

Ketoconazole


The serum concentration of Regorafenib can be increased when it is combined with Ketoconazole.

Labetalol


Regorafenib may increase the bradycardic activities of Labetalol.

Ledipasvir


The serum concentration of Ledipasvir can be increased when it is combined with Regorafenib.

Levobetaxolol


Regorafenib may increase the bradycardic activities of Levobetaxolol.

Levobunolol


Regorafenib may increase the bradycardic activities of Levobunolol.

Lisuride


The risk or severity of adverse effects can be increased when Lisuride is combined with Regorafenib.

Lopinavir


The metabolism of Regorafenib can be decreased when combined with Lopinavir.

Lovastatin


The serum concentration of Lovastatin can be increased when it is combined with Regorafenib.

Luliconazole


The serum concentration of Regorafenib can be increased when it is combined with Luliconazole.

Lumacaftor


The serum concentration of Regorafenib can be decreased when it is combined with Lumacaftor.

Mepindolol


Regorafenib may increase the bradycardic activities of Mepindolol.

Metergoline


The risk or severity of adverse effects can be increased when Metergoline is combined with Regorafenib.

Methylergonovine


The risk or severity of adverse effects can be increased when Methylergometrine is combined with Regorafenib.

Methysergide


The risk or severity of adverse effects can be increased when Methysergide is combined with Regorafenib.

Metipranolol


Regorafenib may increase the bradycardic activities of Metipranolol.

Metoprolol


Regorafenib may increase the bradycardic activities of Metoprolol.

Mifepristone


The serum concentration of Regorafenib can be increased when it is combined with Mifepristone.

Mitotane


The serum concentration of Regorafenib can be decreased when it is combined with Mitotane.

Nadolol


Regorafenib may increase the bradycardic activities of Nadolol.

Naloxegol


The serum concentration of Naloxegol can be increased when it is combined with Regorafenib.

Nebivolol


Regorafenib may increase the bradycardic activities of Nebivolol.

Nefazodone


The metabolism of Regorafenib can be decreased when combined with Nefazodone.

Nelfinavir


The metabolism of Regorafenib can be decreased when combined with Nelfinavir.

Netupitant


The serum concentration of Regorafenib can be increased when it is combined with Netupitant.

Nevirapine


The serum concentration of Regorafenib can be decreased when it is combined with Nevirapine.

Nicergoline


The risk or severity of adverse effects can be increased when Nicergoline is combined with Regorafenib.

Nilotinib


The metabolism of Regorafenib can be decreased when combined with Nilotinib.

Nintedanib


The serum concentration of Nintedanib can be increased when it is combined with Regorafenib.

Olaparib


The metabolism of Regorafenib can be decreased when combined with Olaparib.

Osimertinib


The serum concentration of Regorafenib can be increased when it is combined with Osimertinib.

Ouabain


Ouabain may decrease the cardiotoxic activities of Regorafenib.

Ovine Digoxin Immune Fab


Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Regorafenib.

Oxprenolol


Regorafenib may increase the bradycardic activities of Oxprenolol.

Paclitaxel


The risk or severity of adverse effects can be increased when Paclitaxel is combined with Regorafenib.

Palbociclib


The serum concentration of Regorafenib can be increased when it is combined with Palbociclib.

Pazopanib


The serum concentration of Pazopanib can be increased when it is combined with Regorafenib.

Penbutolol


Regorafenib may increase the bradycardic activities of Penbutolol.

Pentobarbital


The serum concentration of Regorafenib can be decreased when it is combined with Pentobarbital.

Pergolide


The risk or severity of adverse effects can be increased when Pergolide is combined with Regorafenib.

Phenobarbital


The serum concentration of Regorafenib can be decreased when it is combined with Phenobarbital.

Phenytoin


The serum concentration of Regorafenib can be decreased when it is combined with Phenytoin.

Pindolol


Regorafenib may increase the bradycardic activities of Pindolol.

Pitavastatin


The serum concentration of Pitavastatin can be increased when it is combined with Regorafenib.

Posaconazole


The serum concentration of Regorafenib can be increased when it is combined with Posaconazole.

Practolol


Regorafenib may increase the bradycardic activities of Practolol.

Pravastatin


The serum concentration of Pravastatin can be increased when it is combined with Regorafenib.

Primidone


The serum concentration of Regorafenib can be decreased when it is combined with Primidone.

Propafenone


Regorafenib may increase the bradycardic activities of Propafenone.

Propranolol


Regorafenib may increase the bradycardic activities of Propranolol.

Proscillaridin


Proscillaridin may decrease the cardiotoxic activities of Regorafenib.

Ranolazine


The serum concentration of Ranolazine can be increased when it is combined with Regorafenib.

Rifabutin


The serum concentration of Regorafenib can be decreased when it is combined with Rifabutin.

Rifampin


The serum concentration of Regorafenib can be decreased when it is combined with Rifampicin.

Rifapentine


The serum concentration of Regorafenib can be decreased when it is combined with Rifapentine.

Rifaximin


The serum concentration of Rifaximin can be increased when it is combined with Regorafenib.

Rilpivirine


The serum concentration of Rilpivirine can be increased when it is combined with Regorafenib.

Rosuvastatin


The serum concentration of Rosuvastatin can be increased when it is combined with Regorafenib.

Rucaparib


The metabolism of Regorafenib can be decreased when combined with Rucaparib.

Saquinavir


The metabolism of Regorafenib can be decreased when combined with Saquinavir.

Saquinavir Mesylate


The metabolism of Regorafenib can be decreased when combined with Saquinavir.

Sarilumab


The therapeutic efficacy of Regorafenib can be decreased when used in combination with Sarilumab.

Sildenafil


The metabolism of Regorafenib can be decreased when combined with Sildenafil.

Silodosin


The serum concentration of Silodosin can be increased when it is combined with Regorafenib.

Siltuximab


The serum concentration of Regorafenib can be decreased when it is combined with Siltuximab.

Simeprevir


The serum concentration of Regorafenib can be increased when it is combined with Simeprevir.

Simvastatin


The serum concentration of Simvastatin can be increased when it is combined with Regorafenib.

Sotalol


Regorafenib may increase the bradycardic activities of Sotalol.

ST. JOHN'S WORT EXTRACT


The serum concentration of Regorafenib can be decreased when it is combined with St. John's Wort.

Sulfisoxazole


The metabolism of Regorafenib can be decreased when combined with Sulfisoxazole.

Talinolol


Regorafenib may increase the bradycardic activities of Talinolol.

Telaprevir


The metabolism of Regorafenib can be decreased when combined with Telaprevir.

Telithromycin


The serum concentration of Regorafenib can be increased when it is combined with Telithromycin.

Terbutaline


Regorafenib may increase the bradycardic activities of Terbutaline.

Terbutaline Sulfate


Regorafenib may increase the bradycardic activities of Terbutaline.

Tertatolol


Regorafenib may increase the bradycardic activities of Tertatolol.

Ticlopidine


The metabolism of Regorafenib can be decreased when combined with Ticlopidine.

Timolol


Regorafenib may increase the bradycardic activities of Timolol.

Timolol Anhydrous


Regorafenib may increase the bradycardic activities of Timolol.

Tocilizumab


The serum concentration of Regorafenib can be decreased when it is combined with Tocilizumab.

Tolvaptan


The serum concentration of Tolvaptan can be increased when it is combined with Regorafenib.

Topotecan


The serum concentration of Topotecan can be increased when it is combined with Regorafenib.

Trastuzumab


Trastuzumab may increase the cardiotoxic activities of Regorafenib.

Vemurafenib


The serum concentration of Regorafenib can be decreased when it is combined with Vemurafenib.

Venlafaxine


The metabolism of Regorafenib can be decreased when combined with Venlafaxine.

Verapamil


Regorafenib may increase the bradycardic activities of Verapamil.

Vincristine


The excretion of Vincristine can be decreased when combined with Regorafenib.

Voriconazole


The serum concentration of Regorafenib can be increased when it is combined with Voriconazole.

Warfarin


The risk or severity of adverse effects can be increased when Warfarin is combined with Regorafenib.

Ziprasidone


The metabolism of Regorafenib can be decreased when combined with Ziprasidone.

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