Are you taking Glyburide? Are you aware of the dangers of combining Glyburide with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B
Go to source).
Glucomannan: Glucomannan when taken along with Glyburide may influence the intestinal absorption of Glyburide(2✔ ✔Trusted Source
Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man
Go to source).
St.John's wort: St. John's wort interacts with Glyburide resulting in increased risk of hypoglycemia (3✔ ✔Trusted Source
Glyburide
Go to source).
Alcohol and medication interaction
Go to source).
References
1. Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B
https://pubmed.ncbi.nlm.nih.gov/15640378/
2. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man
https://pubmed.ncbi.nlm.nih.gov/6299917/
3. Glyburide
https://www.ncbi.nlm.nih.gov/books/NBK545313/
4. Alcohol and medication interaction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761694/pdf/arh-23-1-40.pdf
5. National Library of Medicine: Glyburide MedlinePlus Drug Information.
https://medlineplus.gov/druginfo/meds/a684058.html
Glyburide Interactions with Food and Herbs
Citrus juices: Avoid citrus juices while taking Glyburide as it may inhibit the intestinal absorption of Glyburide via the inhibition of OATP-B (organic anion-transporting polypeptide B)(1✔ ✔Trusted SourceCitrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B
Go to source).
Glucomannan: Glucomannan when taken along with Glyburide may influence the intestinal absorption of Glyburide(2✔ ✔Trusted Source
Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man
Go to source).
St.John's wort: St. John's wort interacts with Glyburide resulting in increased risk of hypoglycemia (3✔ ✔Trusted Source
Glyburide
Go to source).
Glyburide Interactions with Alcohol
Avoid alcohol while taking glyburide as it may cause disulfiram like reactions such as tachycardia, flushing, vomiting, and increased respiratory rate.(4✔ ✔Trusted SourceAlcohol and medication interaction
Go to source).
When and How to Take Glyburide
- Glyburide is available in the form of a tablet to be taken orally.
- It is usually taken once daily with breakfast.
- Glyburide tablets should be taken around the same time everyday.
- Follow the instructions as directed by the physician.
- Do not exceed or miss the dose.
- Do not discontinue the medication even if you feel better without consulting the physician(5✔ ✔Trusted Source
National Library of Medicine: Glyburide MedlinePlus Drug Information.
Go to source).
References
1. Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B
https://pubmed.ncbi.nlm.nih.gov/15640378/
2. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man
https://pubmed.ncbi.nlm.nih.gov/6299917/
3. Glyburide
https://www.ncbi.nlm.nih.gov/books/NBK545313/
4. Alcohol and medication interaction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761694/pdf/arh-23-1-40.pdf
5. National Library of Medicine: Glyburide MedlinePlus Drug Information.
https://medlineplus.gov/druginfo/meds/a684058.html
