Dhanalakshmi Chinnuswamy
Medically Reviewed by The Medindia Medical Review Team on Oct 27, 2010
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General Information on Propafenone

Generic Name : Propafenone

Pronunciation : proe-pa-FEEN-none

Latest prescription information about Propafenone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.2 | Therapeutic Classification : Antiarrhythmics

Trade Names/Brand Names of Propafenone

India : 

International : 

Rythmol, Rythmol SR, InnoPran XL

Why is Propafenone Prescribed? (Indications)

This medication is an anti-arrhythmic, prescribed for the treatment of abnormal heart rhythm.  It works in the heart to stabilize its action and regulate heartbeat.

When should Propafenone not to be taken? (Contraindications)

Contraindicated in patients with uncontrolled heart failure, marked low blood pressure, slow heart beat and heart block, conduction abnormalities, cardiogenic shock (very low blood pressure due to a heart condition), myasthenia gravis.

What is the dosage of Propafenone?

Adult: PO- Doses should be started under close monitoring of ECG and BP. Usual initial doses: 150 mg 3 times/day, may increase at intervals of 3-4 days up to 300 mg 3 times/day. Dose reduction is recommended in patients weighing <70 kg.

How should Propafenone be taken?

It comes as a tablet to take by mouth. It usually is taken every 8 hours. It should be taken with food.

What are the warnings and precautions for Propafenone?

Caution should be exercised in patients with history of severe pulmonary obstructive diseases, heart failure, cardiac pacemaker, impaired liver or kidney function, elderly, pregnancy and breastfeeding.

Correct electrolyte disturbances before starting treatment.

It may worsen heart failure in patients with preexisting organic heart disease.

It may cause new severe ventricular arrhythmias.

It may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how it affects you.

Patient may develop with increased risk of Brugada Syndrome.

What are the side effects of Propafenone?

  Most Common: Dizziness, chest pain, palpitations, taste disturbance, blurred vision, difficulty in breathing, nausea, constipation, anxiety, fatigue, upper respiratory tract infection, influenza, first-degree heart block, and vomiting.
  Heart: Chest pain, abnormal heart rhythm, slows heart rate, extra heart sounds, swelling.
  Gastrointestinal: Diarrhea, dry mouth, flatulence.
  Central Nervous System: Fatigue, weakness, headache, tremor, depression, drowsiness.
  Respiratory: Upper respiratory tract infection, wheezing, crackles.
  Musculoskeletal: Muscle weakness.
  Skin: Skin discoloration.
  Eye and ENT: Bleeding, eye inflammation, visual disturbance, ringing in the ear, vertigo.

What are the other precautions for Propafenone?

Avoid excess dosage. Consult with your doctor if you are developed with fever, sore throat, or chills.

What are the storage conditions for Propafenone?

Oral: Store at 25C. Store it at room temperature, and in an airtight container. Keep away from excess heat and moisture.


Schedule : H

Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

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