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Promethazine - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Promethazine

Generic Name : Promethazine
Pronunciation : proe meth' a zeen
Latest prescription information about Promethazine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics

Trade Names/Brand Names of Promethazine

India : 


International : 

Phenergan, Promacot, Promethegan

Overview of Promethazine

Note: This brand is not available in US market.

Why is Promethazine Prescribed? (Indications)

This medication is an antihistamine and antiemetic, prescribed for allergic conditions, prevention of motion sickness, and to control nausea and vomiting during and after surgery. It controls nausea and vomiting by changing the actions of chemicals in brain.


When should Promethazine not be taken? (Contraindications)

Contraindicated in patients with asthma, children less than 2 years, and hypersensitivity.
Avoid subcutaneous administration.

What is the dosage of Promethazine?

Allergy- The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary.
Motion Sickness- The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary.
Nausea and Vomiting- Adults- The recommended dosage is 25 mg.

How should Promethazine be taken?

It comes as a tablet, capsule, liquid to take by mouth, with or without food.
It also comes as rectal suppositories, to insert through the rectum.

What are the warnings and precautions for Promethazine?

• Caution should be exercised in patients with history of nervous system problems, bone marrow depression, heart problems, blood disease, increased eye pressure, low blood pressure, liver disease, ulcers, urinary obstruction, enlarged prostate, Parkinson disease, seizures, Reye syndrome, any allergy, who are taking other medications, during pregnancy and breastfeeding.

It may cause drowsiness, dizziness, or blurred vision, do not drive a car operate machinery while taking this medication.

Avoid alcohol consumption.

Patient may develop with increased risk of tissue injury, seizures and Neuroleptic malignant syndrome (NMS); if it is so consult with your doctor.

What are the side effects of Promethazine?

   Central Nervous System : Drowsiness, blurred vision, dizziness, confusion, disorientation, weakness, ringing in the ear, incoordination, fatigue, emotion, nervousness, double vision, sleeplessness, tremors, convulsive seizures, excitement and hallucinations.
   Heart : Increased or decreased blood pressure, fast/slow heart rate and faintness.
   Skin : Skin inflammation, sensitivity to light and hives.
   Blood : Bruising, decrease in white blood cells and platelets.
   Gastrointestinal : Dry mouth, nausea, vomiting and jaundice.
   Respiratory : Asthma, nasal stuffiness and respiratory depression.

What are the other precautions for Promethazine?

It may affect blood sugar level; monitor sugar level regularly.

What are the storage conditions for Promethazine?

Store it at controlled room temperature (20 to 25C).

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CharlieShore, United Kingdom

I took many different sleeping tablets and tranquelisers over forty years. You name it I took it, all legally prescribed. My most recent drugs were Phenergan, Melatonin and zopiclone to help with my insomnia. I recently decided to give them all up due to reeding a book on the Pharma industry. I did cold turkey and suffered bad flu like effects for two weeks. I am now free, my sleep is no worse and perhaps a little better and feel so much better in myself. Mainly with the help of Meditation.

, United States

You need to get the message out to your online pharmacies in india because they are shipping promethazine theoclate in place of phenergan, promethazine, hcl. And it's a very toxic drug. I had a serious allergic reaction to it. Please get the message Out to the online pharmacies: do not substitute promethazine, theoclate avocen, avimax etc..for phenergan, promethazine, hcl...they are not interchangeable nor are they fda approved in the usa Thank you Hl (Posted by , United States Date : 3/21/2012 )

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