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Isotretinoin - Indications, Dosage, Side Effects and Precautions

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Information about Isotretinoin

Generic Name : Isotretinoin
Up-to-date prescription details regarding Isotretinoin are provided here.

Pronunciation : eye soe tret' I noyn

Learn the correct pronunciation of the Isotretinoin, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y56.9 Therapeutic Classification : Miscellaneous Dermatologicals

Trade Names/Brand Names of Isotretinoin

India :

International :


Amnesteem, Claravis, Sotret

Why is Isotretinoin Prescribed? (Indications)

This medication is a retinoid, prescribed for acne and other skin disorders. It reduces skin oil production, changing the characteristics of the skin oil, and preventing abnormal hardening of the skin.

When should Isotretinoin not be taken? (Contraindications)

Contraindicated in pregnant women and in patients with hypersensitivity.

What is the dosage of Isotretinoin?

Adult- PO- The recommended dose range is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks.

How should Isotretinoin be taken?

It comes as a capsule to take by mouth, with food.

What are the warnings and precautions for Isotretinoin?

• Caution should be exercised in patients with history of sugar, high blood cholesterol, mental disorder, suicidal thoughts, liver disease, osteoporosis, eating disorders, diarrhea, rectal bleeding, hearing problems, ringing in the ears, stomach pain, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause drowsiness, vision changes or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid alcohol consumption.

• Avoid exposure to sunlight; otherwise it may cause sunburn easily.

• Monitor pregnancy tests, cholesterol, liver function, blood sugar levels and white blood cell counts regularly while taking this medication.

What are the side effects of Isotretinoin?

Body as a Whole - Allergic reactions.
Heart - Palpitations, fast heart rate and stroke.
Metabolic - Increased blood cholesterol level.
Gastrointestinal - Inflammatory bowel disease, bleeding, inflammation of the gums, peptic ulcer and nausea.
Musculoskeletal - Bone weakness, calcification of tendons and ligaments, premature epiphyseal closure, decrease in bone mineral density including muscle/joint pain.
Central Nervous System - Dizziness, drowsiness, headache, insomnia, lethargy, uneasiness, nervousness, tingling, seizures, stroke, fainting, weakness, suicidal thoughts, suicide attempts, depression, psychosis, aggression and violent behaviors.
Genitourinary - Abnormal menses.
Respiratory - Asthma.

What are the other precautions for Isotretinoin?

It may cause the bones to weaken or thicken abnormally and may increase the risk of certain bone injuries in people who perform some types of physical activity. Consult with your doctor before performing such activities.

What are the storage conditions for Isotretinoin?

Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it away from light.

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