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Aducanumab - Indications, Dosage, Side Effects and Precautions

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Information about Aducanumab

Generic Name : Aducanumab
Pronunciation : add-yoo-CAN-yoo-mab
Latest prescription information about Aducanumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Aducanumab

ADUHELM
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Overview of Aducanumab

Aducanumab is indicated for the treatment of Alzheimer’s disease. It acts by decreasing amyloid beta plaques deposition.

Why is Aducanumab Prescribed? (Indications)

Aducanumab is an amyloid beta-directed antibody prescribed for treating Alzheimer’s disease. 
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When should Aducanumab not be taken? (Contraindications)

• Allergic to Aducanumab
• Pregnancy
• Lactation
• Children

What is the dosage of Aducanumab?

Aducanumab is available as: • Injection: 170 mg/1.7 mL (100 mg/mL) in a single-dose vial
• Injection: 300 mg/3 mL (100 mg/mL) in a single-dose vial

How should Aducanumab be taken?

It should be given as an intravenous (IV) infusion over one hour every four weeks and at least 21 days apart using a sterile, low-protein binding, 0.2 or 0.22 micron in-line filter.
After an initial titration, the recommended dosage is 10 mg/kg body weight Diluted solution should be inspected for particles or discoloration prior to administration.
Stop the infusion upon the first observation of any signs or symptoms consistent with allergic reaction.

What are the side effects of Aducanumab?

• General: Edema, headache, Falls
• Nervous system: Confusion/Delirium/Altered Mental Status/Disorientation

What are the other precautions for Aducanumab?

Amyloid Related Imaging Abnormalities (ARIA): Increased monitoring for ARIA is recommended during the first 8 doses of treatment especially during titration.
The following reactions can occur -
• Allergies
• Angioedema
• and urticaria

What are the storage conditions for Aducanumab?

After dilution, it should be used immediately. If not administered immediately, store the diluted solution in 0.9% Sodium Chloride Injection, refrigerated at 2°C to 8°C for up to 3 days, or at room temperature up to 30°C for up to 12 hours.
Last Updated : 7/5/2021



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