Aducanumab - Indications, Dosage, Side Effects and Precautions

Aducanumab Medication Information

Discover comprehensive details about Aducanumab, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Aducanumab brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Aducanumab

Pronunciation : add-yoo-CAN-yoo-mab

Brand Names or Trade Names of Aducanumab

India :

ADUHELM

Overview of Aducanumab

Aducanumab is indicated for the treatment of Alzheimer’s disease. It acts by decreasing amyloid beta plaques deposition.

Why is Aducanumab Prescribed? (Indications)

Aducanumab is an amyloid beta-directed antibody prescribed for treating Alzheimer’s disease.

When should Aducanumab not be taken? (Contraindications)

• Allergic to Aducanumab
• Pregnancy
• Lactation
• Children

What is the dosage of Aducanumab?

Aducanumab is available as: • Injection: 170 mg/1.7 mL (100 mg/mL) in a single-dose vial
• Injection: 300 mg/3 mL (100 mg/mL) in a single-dose vial

How should Aducanumab be taken?

It should be given as an intravenous (IV) infusion over one hour every four weeks and at least 21 days apart using a sterile, low-protein binding, 0.2 or 0.22 micron in-line filter.
After an initial titration, the recommended dosage is 10 mg/kg body weight Diluted solution should be inspected for particles or discoloration prior to administration.
Stop the infusion upon the first observation of any signs or symptoms consistent with allergic reaction.

What are the side effects of Aducanumab?

• General: Edema, headache, Falls
• Nervous system: Confusion/Delirium/Altered Mental Status/Disorientation

What are the other precautions for Aducanumab?

Amyloid Related Imaging Abnormalities (ARIA): Increased monitoring for ARIA is recommended during the first 8 doses of treatment especially during titration.
The following reactions can occur -
• Allergies
• Angioedema
• and urticaria

What are the storage conditions for Aducanumab?

After dilution, it should be used immediately. If not administered immediately, store the diluted solution in 0.9% Sodium Chloride Injection, refrigerated at 2°C to 8°C for up to 3 days, or at room temperature up to 30°C for up to 12 hours.

Q: What are the special precautions to be followed while administering Aducanumab?

A: A brain MRI is required before starting aducanumab, as ARIA (Amyloid-Related Imaging Abnormalities) may develop during treatment. On brain imaging, ARIA-E can be seen as brain edema or sulcal effusions, while ARIA-H can be seen as microhemorrhage and superficial siderosis().

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