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Chronic Granulomatous Disease
Drugs For Chronic Granulomatous Disease
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Chronic Granulomatous Disease (CGD) | |
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Chronic granulomatous disease (also known as “Bridges–Good syndrome," "Chronic granulomatous disorder," and "Quie syndrome") is an inherited disorder in which immune system cells called phagocytes malfunction. In Chronic Granulomatous Disease (CGD) the white blood cells are unable to produce activated O2 compounds (or anti-oxidants), which normally help a person to fight against infection. Thus, this leads to recurrent life-threatening bacterial and fungal infections. There occurs an excessive accumulation of immune cells into aggregates called granulomas. Diagnosis is done using a test called flow cytometric respiratory burst assay.  Treatment is with antibiotics, antifungal drugs, and interferon-  .
The disease was first described in the 1950s as “a fatal granulomatosus of childhood". More than half of cases of chronic granulomatous disease are transmitted genetically as an X-linked recessive trait. CGD thus occurs only in males. Most of the patients with CGD present during the first 5 years of life. In the rest inheritance is autosomal recessive. No racial predilection is known. |
Latest Publication and Research on Chronic Granulomatous Disease - Updated on 12/05/2011
Transducible form of p47(phox) and p67(phox) compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease. - Published by PubMed
A case of isolated laryngeal candidiasis mimicking laryngeal carcinoma in an immunocompetent individual. - Published by PubMed
Hematopoietic stem cell transplantation for primary immunodeficiency diseases. - Published by PubMed
Identification and functional characterization of two novel mutations in the a-helical loop (residues 484-503) of gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease. - Published by PubMed
Utility of Screening for Chronic Granulomatous Disease in Patients with Inflammatory Bowel Disease. - Published by PubMed
Transducible form of p47(phox) and p67(phox) compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease. - Published by PubMed
A case of isolated laryngeal candidiasis mimicking laryngeal carcinoma in an immunocompetent individual. - Published by PubMed
Hematopoietic stem cell transplantation for primary immunodeficiency diseases. - Published by PubMed
Identification and functional characterization of two novel mutations in the a-helical loop (residues 484-503) of gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease. - Published by PubMed
Utility of Screening for Chronic Granulomatous Disease in Patients with Inflammatory Bowel Disease. - Published by PubMed
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Posted by:
MaryHurley
Posted on: 03/16/2011 Very good article. We have an international support group for CGD. CGD Association c/o Mary Hurley cgda@socal.rr.com www.cgdassociation.org We do not have any CGD patients from India on our database. Please forward this information to your CGD patients as it would be good to link patients from India with other patients from India. Thanks, Mary Hurley
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| Total News Item 9 |
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