Chronic Granulomatous Disease (CGD)
- Causes of Chronic Granulomatous Disease (CGD)
- Symptoms and Signs of Chronic Granulomatous Disease (CGD)
- Diagnosis of Chronic Granulomatous Disease (CGD)
- Treatment, Prognosis and Complications of Chronic Granulomatous Disease (CGD)
- Frequently Asked Questions
- Latest Publication and Research
In Chronic Granulomatous Disease (CGD) the white blood cells are unable to produce activated O2 compounds (or anti-oxidants), which normally help a person to fight against infection. Thus, this leads to recurrent life-threatening bacterial and fungal infections. There occurs an excessive accumulation of immune cells into aggregates called granulomas.
Diagnosis is done using a test called flow cytometric respiratory burst assay.
Treatment is with antibiotics, antifungal drugs, and interferon-.
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The disease was first described in the 1950s as “a fatal granulomatosus of childhood". More than half of cases of chronic granulomatous disease are transmitted genetically as an X-linked recessive trait. CGD thus occurs only in males. Most of the patients with CGD present during the first 5 years of life. In the rest inheritance is autosomal recessive. No racial predilection is known.