Medindia

X

In-Utero Exposure to Low-level Arsenic Revealed by Infant Toenails: Dartmouth Study

by Himabindu Venkatakrishnan on  July 8, 2014 at 10:56 AM Child Health News   - G J E 4
Arsenic exposure before birth can be estimated reliably by examining infant toenails, a Dartmouth College study shows.

The findings appear in the Journal of Exposure Science & Environmental Epidemiology. A PDF of the study is available on request.
 In-Utero Exposure to Low-level Arsenic Revealed by Infant Toenails: Dartmouth Study
In-Utero Exposure to Low-level Arsenic Revealed by Infant Toenails: Dartmouth Study
Advertisement

A growing body of evidence suggests that in utero and early-life exposure to arsenic may have detrimental effects on children, even at the low to moderate levels common in the United States and elsewhere. The fetus starts to develop toenails during the first trimester, making them an accurate measure of exposure to arsenic during the entire gestation. Prior studies that used infant toenails as a biomarker of in utero exposure were conducted in highly exposed populations.

Advertisement
But in a sample of 170 mother-infant pairs from New Hampshire, the researchers determined infant exposure to relatively low arsenic in utero by evaluating infant toenails as a biomarker using plasma mass spectrometry.

The results show that a doubling of maternal postpartum toenail arsenic concentration was associated with a 54 percent increase in infant toenail arsenic concentration as compared with 20 percent for a doubling of maternal urine arsenic concentration. Also, a doubling of maternal toenail and urine arsenic concentrations was associated with a 68 percent increase in infant toenail arsenic concentration. A similar correlation between infant and maternal postpartum toenail concentrations was observed in a group of 130 mother-infant pairs from Rhode Island.

"In utero exposure to arsenic occurs through maternal drinking water and dietary sources, and infant toenails appear to be a reliable biomarker for estimating arsenic exposure during the critical window of gestation," says senior author Professor Margaret Karagas.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: